Could donor stem cells repair failing hearts?

NCT ID NCT04476901

Recruiting now Disease control Sponsor: Joshua M Hare Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests whether injecting donor stem cells (from healthy volunteers) can safely improve heart function in people with a weakened heart muscle not caused by blocked arteries. About 136 adults aged 18-80 with low pumping ability will receive either stem cells or a placebo. The main goal is to see if the stem cells increase the heart's ejection fraction (how much blood it pumps out) after one year.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: allogeneic human mesenchymal stem cells (donor stem cells)
What this could lead to: If this works, it could lead to a new treatment that improves heart function in people with dilated cardiomyopathy, potentially reducing the need for more invasive procedures.
What could go wrong: This is an early Phase 2 trial with only 136 participants, so results may not apply to everyone. Stem cell therapies carry risks like immune reactions or infection, and the placebo group may show similar improvement.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

dilated cardiomyopathy non-familial dilated cardiomyopathy

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

NON-ISCHEMIC DILATED CARDIOMYOPATHY

Contacts and locations

Locations

Stanford University
RECRUITING

Stanford, California, 94304, United States
Texas Heart Institute
RECRUITING

Houston, Texas, 77030, United States
University of Louisville
RECRUITING

Louisville, Kentucky, 40202, United States
University of Miami Miller School of Medicine
RECRUITING

Miami, Florida, 33136, United States

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