Could donor stem cells repair failing hearts?
NCT ID NCT04476901
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests whether injecting donor stem cells (from healthy volunteers) can safely improve heart function in people with a weakened heart muscle not caused by blocked arteries. About 136 adults aged 18-80 with low pumping ability will receive either stem cells or a placebo. The main goal is to see if the stem cells increase the heart's ejection fraction (how much blood it pumps out) after one year.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
allogeneic human mesenchymal stem cells (donor stem cells)
What this could lead to
If this works, it could lead to a new treatment that improves heart function in people with dilated cardiomyopathy, potentially reducing the need for more invasive procedures.
What could go wrong
This is an early Phase 2 trial with only 136 participants, so results may not apply to everyone. Stem cell therapies carry risks like immune reactions or infection, and the placebo group may show similar improvement.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Stanford University
RECRUITINGStanford, California, 94304, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Texas Heart Institute
RECRUITINGHouston, Texas, 77030, United States
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of Louisville
RECRUITINGLouisville, Kentucky, 40202, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Miami Miller School of Medicine
RECRUITINGMiami, Florida, 33136, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••