New hope for advanced breast cancer: drug combo targets resistant tumors
NCT ID NCT05860465
First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a new oral drug called SPH4336 combined with hormone therapy (letrozole or fulvestrant) in people with a common type of advanced breast cancer (HR-positive, HER2-negative) that has worsened after prior treatment. About 254 participants will receive either the drug or a placebo alongside hormone therapy. The goal is to see if the combination can shrink tumors or delay cancer growth.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
SPH4336 tablets (a targeted cancer drug) combined with letrozole or fulvestrant (hormone therapies)
What this could lead to
If successful, this could offer a new treatment option for people with advanced breast cancer whose current therapy has stopped working.
What could go wrong
This is an early-to-mid-stage trial, so the drug may not prove effective or safe enough for approval. Side effects from the combination are possible.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Affiliated Cancer Hospital, Sun Yat-sen University
RECRUITINGGuangzhou, Guangdong, 510060, China
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Anyang Cancer Hospital
RECRUITINGAnyang, He'nan, 455001, China
Contact
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First Affiliated Hospital of Kunming Medical University
RECRUITINGKunming, China
Contact
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Fujian Cancer Hospital
RECRUITINGFuzhou, China
Contact
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General Hospital of Ningxia Medical University
RECRUITINGYinchuan, Ningxia, 750003, China
Contact
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Harbin Medical University cancer Hospital
RECRUITINGHarbin, Heilongjiang, 150081, China
Contact
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Jiangsu Cancer Hospital
RECRUITINGNanjing, Jiangsu, 210009, China
Contact
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Jiangsu Province Hospital
RECRUITINGNanjing, Jiangsu, 210029, China
Contact
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Jilin Cancer Hospital
RECRUITINGChangchun, Jilin, 130012, China
Contact
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Liuzhou people's Hospital
RECRUITINGLiuzhou, Guangxi, 545026, China
Contact
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Peking Union Medical College Hospital
RECRUITINGBeijing, 100730, China
Contact
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Shenzhen Hospital of University of Hong Kong
RECRUITINGShenzhen, China
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The First Affiliated Hospital of Bengbu Medical College
RECRUITINGBengbu, China
Contact
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The First Affiliated Hospital of Henan University of Science and Technology
RECRUITINGLuoyang, He'nan, 450052, China
Contact
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The First Affiliated Hospital of Xi'an Jiao Tong University
RECRUITINGXi’an, Shanxi, 710061, China
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The First Hospital of China Medical University
RECRUITINGShenyang, Liaoning, 110002, China
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The Fourth Hospital of Hebei Medical University
RECRUITINGShijiazhuang, Hebei, 050011, China
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The second people's hospital of neijiang
RECRUITINGNeijiang, Sichuan, 641199, China
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Tianjin Medical University Cancer Institute & Hospital
RECRUITINGTianjin, China
Contact
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Xiangyang Cancer Hospital
RECRUITINGWuhan, Hubei, 441021, China
Contact
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Yunnan Cancer Hospital
RECRUITINGKunming, Yunnan, 650118, China
Contact
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Zhejiang cancer Hospital
RECRUITINGHangzhou, Zhejiang, 310005, China
Contact