8,000-Patient trial aims to find best way to beat deadly staph blood infection

NCT ID NCT05137119

Recruiting now Disease control Sponsor: University of Melbourne Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This massive international trial is testing several antibiotics and treatment strategies to find the best way to reduce deaths from Staphylococcus aureus bloodstream infections. About 8,000 hospitalized adults with a confirmed staph blood infection will be randomly assigned to different antibiotics or approaches, including early switching to oral pills or using PET/CT scans to guide treatment. The main goal is to see which approach lowers the chance of death within 90 days.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Various antibiotics (cefazolin, penicillin, clindamycin, vancomycin/daptomycin) and strategies (early switch to oral antibiotics, PET/CT imaging)
What this could lead to: If successful, this trial could identify the best antibiotic combinations and strategies to lower the death rate from serious staph bloodstream infections.
What could go wrong: This is a large, late-stage trial, but results depend on many variables and may not apply to all patients. Antibiotic resistance or side effects could limit benefits.

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Conditions

The condition(s) this trial relates to.

staphylococcal infection staphylococcus aureus infection

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

STAPHYLOCOCCUS AUREUS BACTEREMIA

Contacts and locations

Locations

Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
Antonius Ziekenhuis
RECRUITING

Nieuwegein, Netherlands
Armadale Hospital
RECRUITING

Perth, Western Australia, 6112, Australia
Auckland City Hospital
RECRUITING

Grafton, Auckland, 1023, New Zealand
Austin Hospital
RECRUITING

Heidelberg, Victoria, 3084, Australia
Barts Health
RECRUITING

London, United Kingdom
Barwon Health - University Hospital Geelong
RECRUITING

Geelong, Victoria, 3220, Australia
Beilinson Hospital
RECRUITING

Petah Tikva, 49100, Israel
Bendigo Health
RECRUITING

Bendigo, Victoria, 3550, Australia
Blacktown Hospital
RECRUITING

Blacktown, New South Wales, 2148, Australia
Box Hill Hospital
RECRUITING

Box Hill, Victoria, 3128, Australia
Brighton and Sussex University Hospitals
RECRUITING

Brighton, United Kingdom
CHU de Rennes - Hôpital Pontchaillou
RECRUITING

Rennes, France
CISSS - Hôpital Cité-de-la-Santé Hospital
RECRUITING

Laval, Quebec, Canada
Cairns Hospital
RECRUITING

Cairns, Queensland, 4870, Australia
Cambridge University Hospitals
NOT_YET_RECRUITING

Cambridge, United Kingdom
Canberra Hospital
RECRUITING

Garran, Australia Capital Territory, 2605, Australia
Cardiff and Vale University
RECRUITING

Cardiff, United Kingdom
Charité University Hospital Berlin
RECRUITING

Berlin, Germany
Charlotte Maxeke Johannesburg Academic Hospital
NOT_YET_RECRUITING

Johannesburg, South Africa
Christchurch Hospital
NOT_YET_RECRUITING

Christchurch, Canterbury, 8011, New Zealand
Concord Repatriation and General Hospital
RECRUITING

Concord, New South Wales, 2139, Australia
Eastern Health - Health Sciences Centre (Memorial University)
RECRUITING

St. John's, Newfoundland and Labrador, A1B3V6, Canada
Eastern Regional Health Authority - St. Clare's Mercy Hospital
RECRUITING

St. John's, Newfoundland and Labrador, Canada
Fiona Stanley Hospital
RECRUITING

Murdoch, Western Australia, 6150, Australia
Flinders Medical Centre
RECRUITING

Bedford Park, South Australia, 5042, Australia
Foothills Medical Center
RECRUITING

Calgary, Alberta, T2N4Z6, Canada
Frankston Hospital
NOT_YET_RECRUITING

Frankston, Victoria, 3199, Australia
Fraser Health Authority - Surrey Memorial Hospital
RECRUITING

Surrey, British Columbia, Canada
Gold Coast University Hospital
RECRUITING

Southport, Queensland, 4215, Australia
Goulburn Valley Health
COMPLETED

Shepparton, Victoria, 3630, Australia
Grace Hospital
RECRUITING

Winnipeg, Manitoba, R3J 3M7, Canada
Grampians Health
RECRUITING

Ballarat, Victoria, 3350, Australia
Great Ormond Street
NOT_YET_RECRUITING

London, United Kingdom
Greater Glasgow and Clyde
NOT_YET_RECRUITING

Glasgow, United Kingdom
Guys and St Thomas'
RECRUITING

London, United Kingdom
Hamilton Health Sciences - Hamilton General Hospital
RECRUITING

Hamilton, Ontario, L8P1A2, Canada
Hamilton Health Sciences - Juravinski Hospital
RECRUITING

Hamilton, Ontario, Canada
Health Sciences Centre Winnipeg
RECRUITING

Winnipeg, Manitoba, R3A1R9, Canada
Helen Joseph Hospital
ACTIVE_NOT_RECRUITING

Johannesburg, South Africa
Helsingborg Hospital
RECRUITING

Helsingborg, Sweden
Houston Methodist Research Institute
RECRUITING

Houston, Texas, 77030, United States
Hull University Teaching Hospitals
RECRUITING

Hull, United Kingdom
Hutt Valley Hospital
RECRUITING

Boulcott, Lower Hutt, 5010, New Zealand
Hôpital Régional de Saint Jérôme
RECRUITING

Saint-Jérôme, Quebec, J7Z5T3, Canada
Ikazia Ziekenhuis
RECRUITING

Rotterdam, Netherlands
Imperial College Healthcare
RECRUITING

London, United Kingdom
Ipswich Hospital
RECRUITING

Ipswich, Queensland, 4305, Australia
Jeroen Bosch Hospital
RECRUITING

's-Hertogenbosch, Netherlands
Jewish General Hospital
RECRUITING

Montreal, Quebec, H3T1E2, Canada
John Hunter Children's Hospital
RECRUITING

Newcastle, New South Wales, 2305, Australia
John Hunter Hospital
RECRUITING

New Lambton Heights, New South Wales, 2305, Australia
KidzFirst
RECRUITING

Auckland, 2025, New Zealand
Kings College Hospital
NOT_YET_RECRUITING

London, United Kingdom
Kingston Health Sciences Centre - Kingston General Hospital
RECRUITING

Kingston, Ontario, K7L2V7, Canada
La Trobe Regional Hospital
NOT_YET_RECRUITING

Traralgon, Victoria, 3844, Australia
Launceston Hospital
RECRUITING

Launceston, Tasmania, 7250, Australia
Leeds Teaching Hospitals
RECRUITING

Leeds, United Kingdom
Liverpool Hospital
RECRUITING

Liverpool, New South Wales, 2170, Australia
Liverpool University Hospital
RECRUITING

Liverpool, United Kingdom
Logan Hospital
NOT_YET_RECRUITING

Meadowbrook, Queensland, 4131, Australia
London Health Sciences Centre - University Hospital, LHSC
COMPLETED

London, Ontario, Canada
Lothian Western General
RECRUITING

Edinburgh, United Kingdom
Lyell McEwin Hospital
RECRUITING

Adelaide, South Australia, 5112, Australia
Maastricht UMC+
RECRUITING

Maastricht, Netherlands
Manchester University Hospitals
RECRUITING

Manchester, United Kingdom
McGill University Health Centre - Montral General Hospital
RECRUITING

Montreal, Quebec, H4A3J1, Canada
McGill University Health Centre - Montreal Children's Hospital
NOT_YET_RECRUITING

Montreal, Quebec, Canada
McGill University Health Centre - Royal Victoria Hospital
RECRUITING

Montreal, Quebec, Canada
Middlemore Hospital
RECRUITING

Otahuhu, Auckland, 1640, New Zealand
Monash Children's Hospital
NOT_YET_RECRUITING

Clayton, Victoria, 3168, Australia
Monash Health - Monash Medical Centre & Jesse McPherson Private Hospital
RECRUITING

Clayton, Victoria, 3168, Australia
NHS Forth Valley
NOT_YET_RECRUITING

Stirling, United Kingdom
NHS Golden Jubilee
NOT_YET_RECRUITING

Glasgow, United Kingdom
NHS Grampian
NOT_YET_RECRUITING

Aberdeen, United Kingdom
NHS Tayside
NOT_YET_RECRUITING

Dundee, United Kingdom
National University Hospital
RECRUITING

Singapore, 119228, Singapore
Nepean Hospital
RECRUITING

Kingswood, New South Wales, 2747, Australia
Newcastle Upon Tyne Hospitals
RECRUITING

Newcastle upon Tyne, United Kingdom
Niagara Health - Niagara Falls Site
RECRUITING

Niagara Falls, Ontario, Canada
Niagara Health - St. Catharines Site
RECRUITING

St. Catharines, Ontario, L2S 0A9, Canada
North Bristol
RECRUITING

Bristol, United Kingdom
North Shore Hospital
RECRUITING

Takapuna, Auckland, 0620, New Zealand
Nottingham University Hospitals
NOT_YET_RECRUITING

Nottingham, United Kingdom
Orange Health Service
RECRUITING

Orange, New South Wales, 2800, Australia
Otto-von-Guericke-university Magdeburg
RECRUITING

Magdeburg, Germany
Oxford University Hospitals
RECRUITING

Oxford, United Kingdom
Perth Children's Hospital
RECRUITING

Nedlands, Western Australia, 6009, Australia
Peter Lougheed Centre
RECRUITING

Calgary, Alberta, T1Y 6J4, Canada
Prince of Wales Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
Princess Alexandra Hospital
NOT_YET_RECRUITING

Woolloongabba, Queensland, 4102, Australia
Queensland Children's Hospital
RECRUITING

South Brisbane, Queensland, 4101, Australia
Radboud University Medical Center
RECRUITING

Nijmegen, Netherlands
Rahima Moosa Mother and Child Hospital
NOT_YET_RECRUITING

Johannesburg, South Africa
Rambam Health Care Campus
RECRUITING

Haifa, 310960, Israel
Redcliffe Hospital
RECRUITING

Redcliffe, Queensland, 4020, Australia
Richmond Hospital
RECRUITING

Richmond, British Columbia, V6X1A2, Canada
Rijnstate Hospital
ACTIVE_NOT_RECRUITING

Arnhem, Netherlands
Robina Hospital
RECRUITING

Robina, Queensland, 4226, Australia
Rockyview Hospital
RECRUITING

Calgary, Alberta, T2V 1P9, Canada
Royal Brisbane and Women's Hospital
RECRUITING

Herston, Queensland, 4029, Australia
Royal Children's Hospital Melbourne
RECRUITING

Parkville, Victoria, 3052, Australia
Royal Cornwall Hospitals
NOT_YET_RECRUITING

Cornwall, United Kingdom
Royal Darwin Hospital
RECRUITING

Tiwi, Northern Territory, 0811, Australia
Royal Devon University Healthcare
NOT_YET_RECRUITING

Devon, United Kingdom
Royal Free London
RECRUITING

London, United Kingdom
Royal Hobart Hospital
NOT_YET_RECRUITING

Hobart, Tasmania, 7000, Australia
Royal Melbourne Hospital
RECRUITING

Parkville, Victoria, 3050, Australia
Royal Perth Hospital
RECRUITING

Perth, Western Australia, 6000, Australia
Royal Prince Alfred Hospital
RECRUITING

Camperdown, New South Wales, 2050, Australia
SUS Malmö
RECRUITING

Malmö, Sweden
Sault Area Hospital
COMPLETED

Sault Ste. Marie, Ontario, P6B 0A8, Canada
Schneider Hospital
RECRUITING

Petah Tikva, Israel
Science Tokyo University Hospital
RECRUITING

Ichikawa, Chiba, 272-0827, Japan
Sheba Medical Centre
RECRUITING

Ramat Gan, 49100, Israel
Sheffield Teaching Hospitals
NOT_YET_RECRUITING

Sheffield, United Kingdom
Sinai Heath System - Mount Sinai Hospital
RECRUITING

Toronto, Ontario, M5G1X5, Canada
Singapore General Hospital
RECRUITING

Singapore, 168753, Singapore
South Health Campus
RECRUITING

Calgary, Alberta, T3M 1M4, Canada
South Tees Hospitals
RECRUITING

South Tees, United Kingdom
St George Hospital
NOT_YET_RECRUITING

Kogarah, New South Wales, 2217, Australia
St Vincent's Hospital Sydney
RECRUITING

Darlinghurst, New South Wales, 2010, Australia
St. Boniface Hospital
RECRUITING

Winnipeg, Manitoba, R2H 2A6, Canada
Starship Hospital
RECRUITING

Auckland, 1023, New Zealand
Sunnybrook Health Sciences Centre
RECRUITING

Toronto, Ontario, M4N3M5, Canada
Sunshine Coast University Hospital
RECRUITING

Birtinya, Queensland, 4575, Australia
Swansea Bay University Health Board
RECRUITING

Swansea, United Kingdom
Sydney Children's Hospital
RECRUITING

Randwick, New South Wales, 2031, Australia
Tan Tock Seng Hospital
RECRUITING

Singapore, 308433, Singapore
Tauranga Hospital
RECRUITING

Tauranga, 3112, New Zealand
The Children's Hospital at Westmead
RECRUITING

Westmead, New South Wales, 2145, Australia
The Ottawa Hospital - Civic Campus
RECRUITING

Ottawa, Ontario, K1H8L6, Canada
The Ottawa Hospital - General Campus
RECRUITING

Ottawa, Ontario, Canada
Toronto East Health Network - Michael Garron Hospital
RECRUITING

East York, Ontario, M4C3E7, Canada
Treant Ziekenhuis
RECRUITING

Emmen, Netherlands
UMC Groningen
ACTIVE_NOT_RECRUITING

Groningen, Netherlands
Unity Health - St Michael's Hospital
RECRUITING

Toronto, Ontario, M1L 1W1, Canada
Unity Health Toronto - St Joseph's Health Centre
RECRUITING

Toronto, Ontario, Canada
University College London Hospitals
RECRUITING

London, United Kingdom
University Health Network - Toronto General Hospital
COMPLETED

East York, Ontario, M5G2C4, Canada
University Health Network - Toronto Western Hospital
COMPLETED

Toronto, Ontario, Canada
University Hospital Carl Gustav Carus Dresden
RECRUITING

Dresden, Germany
University Hospital Southampton
RECRUITING

Southampton, United Kingdom
University Hospitals Birmingham
RECRUITING

Birmingham, United Kingdom
University Hospitals Bristol and Weston
RECRUITING

Bristol, United Kingdom
University Hospitals of North Midlands
NOT_YET_RECRUITING

Stoke, United Kingdom
University Medical Center Utrecht
RECRUITING

Utrecht, Netherlands
University Medical Centre Freiburg
RECRUITING

Freiburg im Breisgau, Germany
University of Alberta Hospital
RECRUITING

Edmonton, Alberta, T6G2B7, Canada
University of Sherbrooke Health Centre - Hospital Fleurimont
RECRUITING

Sherbrooke, Quebec, J1H 5H3, Canada
University of Sherbrooke Health Centre - Hotel Dieu
RECRUITING

Sherbrooke, Quebec, Canada
Vancouver General Hospital
RECRUITING

Vancouver, British Columbia, V5Z1M9, Canada
Waikato Hospital
RECRUITING

Hamilton, 3240, New Zealand
Wellington Hospital
RECRUITING

Newtown, Wellington Region, 6021, New Zealand
Western Health - Footscray, Joan Kirner & Sunshine Hospitals
RECRUITING

Footscray, Victoria, 3011, Australia
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia
Whangarei Hospital
NOT_YET_RECRUITING

Whangarei, 0148, New Zealand
Whittington Health
RECRUITING

London, United Kingdom
Wollongong Hospital
RECRUITING

Wollongong, New South Wales, 2500, Australia
Women and Children's Hospital
NOT_YET_RECRUITING

North Adelaide, South Australia, 5006, Australia
Women's and Children's Hospital
NOT_YET_RECRUITING

North Adelaide, South Australia, 5006, Australia

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