New hope for DVT patients when blood thinners fail

NCT ID NCT06486181

Not yet recruiting Disease control Sponsor: Rush University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests whether using a catheter to deliver clot-busting drugs or a device to physically remove the clot can help people with acute deep vein thrombosis (DVT) who do not improve after one week of blood thinners. About 100 adults aged 18 to 75 with acute DVT in the leg will be randomly assigned to receive either the endovascular procedure plus standard care or standard care alone. Researchers will compare symptom scores and clot burden to see if the extra treatment is safe and effective.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: catheter-directed thrombolysis or mechanical thrombectomy
What this could lead to: If it works, this could provide a safe and effective second-line option for people with acute DVT who do not respond to initial blood thinner therapy.
What could go wrong: This is a relatively small Phase 4 trial (100 participants) and has not yet started recruiting. The procedures carry risks like bleeding or vessel damage, and results may not apply to all DVT patients.

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Conditions

The condition(s) this trial relates to.

femoral vein thrombophlebitis venous thromboembolism Venous Thrombosis

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

DEEP VENOUS THROMBOSIS

Contacts and locations

Locations

RUSH University Medical Center

Chicago, Illinois, 60612, United States

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