Radiation plus immunotherapy: a one-two punch against advanced melanoma?
NCT ID NCT06767306
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This phase 2 trial is testing whether adding a precise type of radiation called SBRT to standard immunotherapy helps people with advanced melanoma that has spread to a few spots live longer. About 129 adults with untreated, stage IV melanoma will either get immunotherapy alone or immunotherapy plus SBRT. The study will track survival and cancer progression over several years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Stereotactic body radiotherapy (SBRT) plus immunotherapy (immune checkpoint inhibitor)
What this could lead to
If it works, this could show that adding precise radiotherapy to immunotherapy helps people with advanced melanoma live longer or keep the cancer from growing.
What could go wrong
This is a relatively small, early-phase trial (129 people) without a direct comparison group, so results may not be conclusive. Radiotherapy can cause side effects like fatigue or skin irritation, and combining treatments may increase immune-related reactions.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Melanoma Institute Australia
RECRUITINGWollstonecraft, New South Wales, 2065, Australia
Contact
Contact Phone: •••-•••-•••• Email: •••••@•••••
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Princess Alexandra Hospital
RECRUITINGWoolloongabba, Queensland, 4102, Australia
Contact
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Princess Margaret Cancer Centre
RECRUITINGToronto, Ontario, M5G 2C4, Canada
Contact
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The Alfred Hospital
RECRUITINGMelbourne, Victoria, 3004, Australia
Contact
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Westmead Hospital
RECRUITINGWestmead, New South Wales, 2145, Australia
Contact