Radiation plus immunotherapy: a one-two punch against advanced melanoma?

NCT ID NCT06767306

Recruiting now Disease control Sponsor: Melanoma Institute Australia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This phase 2 trial is testing whether adding a precise type of radiation called SBRT to standard immunotherapy helps people with advanced melanoma that has spread to a few spots live longer. About 129 adults with untreated, stage IV melanoma will either get immunotherapy alone or immunotherapy plus SBRT. The study will track survival and cancer progression over several years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Stereotactic body radiotherapy (SBRT) plus immunotherapy (immune checkpoint inhibitor)
What this could lead to: If it works, this could show that adding precise radiotherapy to immunotherapy helps people with advanced melanoma live longer or keep the cancer from growing.
What could go wrong: This is a relatively small, early-phase trial (129 people) without a direct comparison group, so results may not be conclusive. Radiotherapy can cause side effects like fatigue or skin irritation, and combining treatments may increase immune-related reactions.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

metastatic melanoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MELANOMA METASTATIC

Contacts and locations

Locations

Melanoma Institute Australia
RECRUITING

Wollstonecraft, New South Wales, 2065, Australia
Princess Alexandra Hospital
RECRUITING

Woolloongabba, Queensland, 4102, Australia
Princess Margaret Cancer Centre
RECRUITING

Toronto, Ontario, M5G 2C4, Canada
The Alfred Hospital
RECRUITING

Melbourne, Victoria, 3004, Australia
Westmead Hospital
RECRUITING

Westmead, New South Wales, 2145, Australia

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