New drug combo aims to slow spread of prostate cancer

NCT ID NCT06120491

Ongoing Disease control Sponsor: AstraZeneca Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This Phase 3 trial tests whether adding the experimental drug saruparib to standard hormone therapy can slow cancer growth in men with metastatic prostate cancer that still responds to hormone treatment. About 1,889 men will receive either saruparib or a placebo, plus a hormone drug chosen by their doctor. The main goal is to see how long it takes for the cancer to worsen or for death to occur.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Saruparib (AZD5305) combined with a hormone therapy (abiraterone, darolutamide, or enzalutamide)

What this could lead to

If successful, this could provide a new treatment option that delays cancer progression in men with metastatic prostate cancer.

What could go wrong

This is an early-stage Phase 3 trial, and results may not confirm benefit. Side effects from the drug combination are possible, and not all participants may respond.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

metastatic prostate carcinoma prostate cancer

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

METASTATIC CASTRATION-SENSITIVE PROSTATE CANCER

Contacts and locations

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Locations

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Chandler, Arizona, 85224, United States
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Gilbert, Arizona, 85234, United States
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Phoenix, Arizona, 85054, United States
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Tucson, Arizona, 85741, United States
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Little Rock, Arkansas, 72205, United States
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Springdale, Arkansas, 72762, United States
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Bakersfield, California, 93301, United States
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Fountain Valley, California, 92708, United States
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Fullerton, California, 92835, United States
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Los Angeles, California, 90073, United States
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Montebello, California, 90640, United States
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San Francisco, California, 94115, United States
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Santa Barbara, California, 93105, United States
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Santa Monica, California, 90404, United States
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Santa Rosa, California, 95403, United States
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Golden, Colorado, 80401, United States
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Lakewood, Colorado, 80228, United States
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New Haven, Connecticut, 06510, United States
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Atlanta, Georgia, 30318, United States
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Glenview, Illinois, 60026, United States
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Lake Barrington, Illinois, 60010, United States
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Fort Wayne, Indiana, 46804, United States
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Indianapolis, Indiana, 46202, United States
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Westwood, Kansas, 66205, United States
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Shreveport, Louisiana, 71103, United States
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Scarborough, Maine, 04074, United States
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Baltimore, Maryland, 21201, United States
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Baltimore, Maryland, 21287, United States
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Bethesda, Maryland, 20817, United States
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Towson, Maryland, 21204, United States
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Upper Marlboro, Maryland, 20774, United States
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Grand Rapids, Michigan, 49503, United States
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Troy, Michigan, 48084, United States
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Rochester, Minnesota, 55905, United States
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Bozeman, Montana, 59715, United States
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Las Vegas, Nevada, 89102, United States
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Las Vegas, Nevada, 89148, United States
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Camden, New Jersey, 08103, United States
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Albuquerque, New Mexico, 87109, United States
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East Syracuse, New York, 13057, United States
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New Hyde Park, New York, 11042, United States
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New York, New York, 10029, United States
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Syracuse, New York, 13210, United States
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Durham, North Carolina, 27710, United States
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Cincinnati, Ohio, 45212, United States
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Cincinnati, Ohio, 45219, United States
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Cleveland, Ohio, 44111, United States
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Cleveland, Ohio, 44124, United States
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Columbus, Ohio, 43210, United States
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Portland, Oregon, 97227, United States
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Bala-Cynwyd, Pennsylvania, 19004-1017, United States
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Philadelphia, Pennsylvania, 19104, United States
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Pittsburgh, Pennsylvania, 15212, United States
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Providence, Rhode Island, 02903, United States
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Myrtle Beach, South Carolina, 29572, United States
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North Charleston, South Carolina, 29406, United States
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Sioux Falls, South Dakota, 57105, United States
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Germantown, Tennessee, 38138, United States
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Nashville, Tennessee, 37203, United States
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Dallas, Texas, 75231, United States
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Houston, Texas, 77025, United States
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San Antonio, Texas, 78229, United States
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Sugar Land, Texas, 77479, United States
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Tyler, Texas, 75702, United States
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Wichita Falls, Texas, 76310, United States
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Salt Lake City, Utah, 84106, United States
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Salt Lake City, Utah, 84132, United States
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St. George, Utah, 84790, United States
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Fairfax, Virginia, 22031, United States
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Spokane, Washington, 99202, United States
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Tacoma, Washington, 98405, United States
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Chermside, 4032, Australia
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Darlinghurst, 2010, Australia
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Hyde Park, 4812, Australia
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Kurralta Park, 5037, Australia
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Melbourne, 3000, Australia
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South Brisbane, 4101, Australia
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Graz, 8036, Austria
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Innsbruck, 6020, Austria
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Krems, 3500, Austria
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Linz, 4020, Austria
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Vienna, 1020, Austria
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Vienna, 1090, Austria
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Ghent, 9000, Belgium
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Kortrijk, 8500, Belgium
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Leuven, 3000, Belgium
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Curitiba, 80810-050, Brazil
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Pelotas, 96020-080, Brazil
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Porto Alegre, 90035-001, Brazil
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Rio de Janeiro, 22775-001, Brazil
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Salvador, 41950-640, Brazil
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São Paulo, 01246-000, Brazil
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São Paulo, 01323-903, Brazil
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São Paulo, 05652000, Brazil
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Calgary, Alberta, T2N 5G2, Canada
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Calgary, Alberta, T2V 1P9, Canada
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Abbotsford British Columbia, British Columbia, V2S 2J4, Canada
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Abbotsford British Columbia, British Columbia, V2T 1X8, Canada
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Kelowna, British Columbia, V1Y 5L3, Canada
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Vancouver, British Columbia, V5Z 1H7, Canada
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Kingston, Ontario, K7L 5P9, Canada
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Mississauga, Ontario, L5M 2N1, Canada
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Newmarket, Ontario, L3Y 2P9, Canada
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Ottawa, Ontario, K1H 8L6, Canada
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Toronto, Ontario, M4N 3M5, Canada
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Toronto, Ontario, M5G 2M9, Canada
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Chicoutimi, Quebec, G7H 5H6, Canada
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Greenfield Park, Quebec, J4V 2H1, Canada
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Montreal, Quebec, H2X 3E4, Canada
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Montreal, Quebec, H3T 1E2, Canada
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Montreal, Quebec, H4A 3J1, Canada
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Québec, Quebec, G1J 1Z4, Canada
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Saskatoon, Saskatchewan, S7N 4H4, Canada
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Concepción, 4070196, Chile
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La Serena, 1720430, Chile
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Santiago, 7500787, Chile
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Santiago, 7520349, Chile
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Santiago, 8241479, Chile
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Santiago, 8330032, Chile
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Temuco, 4781156, Chile
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Viña del Mar, 2540488, Chile
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Beijing, 100021, China
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Beijing, 100034, China
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Beijing, 100050, China
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Beijing, 100142, China
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Beijing, CN-100730, China
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Changchun, 130021, China
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Changsha, 410013, China
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Chengdu, 610041, China
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Chongqing, 400030, China
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Chongqing, 400038, China
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Dongguan, 523009, China
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Guangzhou, 510180, China
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Guilin, 541000, China
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Hangzhou, 310009, China
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Hangzhou, 310022, China
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Harbin, 150081, China
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Jiaxing, 314001, China
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Jinan, 250021, China
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Lanzhou, 730030, China
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Nanchang, 330000, China
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Nanchang, 330029, China
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Nanjing, 2100008, China
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Nantong, 226361, China
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Ningbo, 315010, China
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Shandong, China
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Shanghai, 200002, China
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Shanghai, 200080, China
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Shenyang, 110001, China
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Shenyang, 110004, China
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Suining, 629000, China
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Taiyuan, 030000, China
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Tianjin, 300211, China
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Wenzhou, 325000, China
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Wuhan, 430079, China
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Xi'an, 710061, China
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Yantai, 264000, China
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Zhengzhou, 450008, China
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Angers, 49055, France
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Bayonne, 64109, France
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Bordeaux, 33000, France
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Caen, 41076, France
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Clermont-Ferrand, 63011, France
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Créteil, 94000, France
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Lyon, 69373, France
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Montpellier, 34298, France
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Nice, 06100, France
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Nîmes, 30029, France
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Paris, 75679, France
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Pierre-Bénite, 69495, France
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Poitiers, 86021, France
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Quimper, 29107, France
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Rennes, 35033, France
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Strasbourg, 67200, France
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Tours, 37000, France
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Vandœuvre-lès-Nancy, 54519, France
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Bergisch Gladbach, 51465, Germany
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Berlin, 10117, Germany
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Braunschweig, 38126, Germany
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Cologne, 50968, Germany
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Dresden, 01307, Germany
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Duisburg, 47169, Germany
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Frankfurt, 60488, Germany
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Frankfurt am Main, 60590, Germany
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Freiburg im Breisgau, 79106, Germany
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Hamburg, 20246, Germany
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Heidelberg, 69120, Germany
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Herne, 44625, Germany
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Homburg, 66421, Germany
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Mannheim, 68167, Germany
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Marburg, 35043, Germany
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Mettmann, 40822, Germany
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München, 81675, Germany
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Münster, 48149, Germany
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Nürtingen, 72622, Germany
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Regensburg, 93053, Germany
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Trier, 54292, Germany
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Tübingen, 72076, Germany
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Ulm, 89081, Germany
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Budapest, 1122, Hungary
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Budapest, 1145, Hungary
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Debrecen, 4032, Hungary
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Miskolc, 3526, Hungary
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Szeged, 6725, Hungary
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Bangalore, 560027, India
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Calicut, 673601, India
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Kanpur, 208005, India
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Kolkata, 700099, India
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Nagpur, 440001, India
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New Delhi, 110085, India
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New Delhi, 11029, India
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Pune, 411004, India
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Vadodara, 391760, India
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Varanasi, 221005, India
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Bari, 70124, Italy
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Genoa, 16132, Italy
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Meldola, 47014, Italy
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Milan, 20132, Italy
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Milan, 20133, Italy
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Naples, 80131, Italy
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Padova, 35128, Italy
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Rome, 00168, Italy
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Rozzano, 20089, Italy
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Terni, 05100, Italy
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Trento, 38100, Italy
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Chiba, 260-8717, Japan
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Fukuoka, 811-1347, Japan
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Fukuoka, 812-8582, Japan
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Hirakata-shi, 573-1191, Japan
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Hirosaki-shi, 036-8563, Japan
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Kanazawa, 920-8641, Japan
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Kashihara-shi, 634-8522, Japan
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Kawagoe-shi, 350-8550, Japan
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Kisarazu-shi, 292-8535, Japan
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Kita-gun, 761-0793, Japan
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Kobe, 650-0047, Japan
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Kumamoto, 860-0008, Japan
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Kyoto, 606-8507, Japan
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Maebashi, 371-8811, Japan
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Nagano, 381-8551, Japan
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Nagasaki, 852-8501, Japan
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Nagoya, 466-8560, Japan
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Nagoya, 466-8650, Japan
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Osaka, 541-8567, Japan
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Osakasayama-shi, 589-8511, Japan
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Sagamihara-shi, 252-0375, Japan
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Sakura-shi, 285-8741, Japan
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Sapporo, 060-8638, Japan
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Shiwa-gun, 028-3695, Japan
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Suita-shi, 565-0871, Japan
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Tsu, 514-8507, Japan
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Yokohama, 232-0024, Japan
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Yufu-shi, 879-5593, Japan
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George Town, 10450, Malaysia
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Johor Bahru, 81100, Malaysia
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Kota Kinabalu, 88996, Malaysia
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Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, 59100, Malaysia
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Kuching, 93586, Malaysia
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Amsterdam, 1066 CX, Netherlands
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Hilversum, 1213 XZ, Netherlands
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Nijmegen, 6525 GA, Netherlands
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Bellavista, CALLAO 2, Peru
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Lima, 15036, Peru
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Lima, 15082, Peru
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Lima, 15102, Peru
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Lima, 34, Peru
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Lima, LIMA 29, Peru
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Bydgoszcz, 85-796, Poland
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Koszalin, 75-581, Poland
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Poznan, 61-731, Poland
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Rzeszów, 35-001, Poland
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Warsaw, 04-073, Poland
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Wroclaw, 53-329, Poland
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Daejeon, 35015, South Korea
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Seoul, 03080, South Korea
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Seoul, 03722, South Korea
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Seoul, 05505, South Korea
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Seoul, 06351, South Korea
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Seoul, 06591, South Korea
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Suwon, 16247, South Korea
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Barcelona, 08035, Spain
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L'Hospitalet de Llobregat, 08908, Spain
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Lugo, 27003, Spain
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Madrid, 28034, Spain
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Madrid, 28040, Spain
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Madrid, 28041, Spain
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Kaohsiung City, 833, Taiwan
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Taoyuan, 333, Taiwan
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Bangkok, 10210, Thailand
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Bangkok, 10700, Thailand
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Khlong Luang, 12120, Thailand
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Songkhla, 90110, Thailand
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Ankara, 06340, Turkey (Türkiye)
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Cordaleo, 35575, Turkey (Türkiye)
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Fatih-Istanbul, 34098, Turkey (Türkiye)
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Istanbul, 34722, Turkey (Türkiye)
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Aberdeen, AB25 2ZN, United Kingdom
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Birmingham, B15 2GW, United Kingdom
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