New safety bundle aims to reduce breathing tube risks in fragile newborns

NCT ID NCT05838690

Recruiting now Disease control Sponsor: Children's Hospital of Philadelphia Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a personalized safety bundle (PINS) designed to reduce complications when placing a breathing tube in newborns in the NICU. The bundle includes a tailored plan covering risk assessment, when to intubate, medications, equipment, and provider expertise. Researchers will track adverse events in 3,000 infants to see if the bundle improves safety.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Personalized Intubation Safety (PINS) Bundle
What this could lead to: If it works, this could make emergency breathing tube placement safer for thousands of fragile newborns, reducing life-threatening complications.
What could go wrong: This is a large but early-stage quality-improvement study, not a drug trial. The bundle may not reduce complications in all NICUs, and results may not apply outside this hospital system.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INFANT INTUBATION COMPLICATION

Contacts and locations

Locations

CHU Sainte-Justine
ACTIVE_NOT_RECRUITING

Montreal, Quebec, QC H3T 1C5, Canada
Dartmouth-Hitchcock Clinic
RECRUITING

Lebanon, New Hampshire, 03756, United States
Penn State Milton S. Hershey Medical Center
RECRUITING

Hershey, Pennsylvania, 17033, United States
University of Arkansas Medical Sciences
RECRUITING

Little Rock, Arkansas, 72205, United States
University of Colorado - Denver
RECRUITING

Denver, Colorado, 80204, United States
University of Washington
RECRUITING

Seattle, Washington, 98195, United States
WakeMed Health & Hospitals
RECRUITING

Raleigh, North Carolina, 27610, United States
Yale-New Haven Hospital
RECRUITING

New Haven, Connecticut, 06510, United States

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