New hope for hard-to-treat blood cancers? early trial stopped short

NCT ID NCT06563804

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested a new drug called S227928, alone or with another drug (venetoclax), in people with certain blood cancers (AML, MDS/AML, or CMML) that returned or didn't respond to prior therapy. The goal was to find a safe dose and see if it helps. The trial was terminated early after enrolling 13 participants, so results are limited.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelomonocytic leukemia Myelodysplastic Syndromes Recurrence

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Contacts and locations

Locations

  • CHU de Bordeaux - Hopital du Haut Levêque

    Pessac, 33604, France

  • Chu de Nice - Hôpital L'archet 1

    Nice, 062000, France

  • City of Hope

    Duarte, California, 91010, United States

  • Fred Hutch Cancer Center

    Seattle, Washington, 98109, United States

  • Helsinki University Hospital - Comprehensive Cancer Center

    Helsinki, 00029, Finland

  • Institut Gustave Roussy

    Villejuif, 94800, France

  • Institut Paoli Calmette

    Marseille, 13009, France

  • Klinikum rechts der Isar der TU München

    München, 81675, Germany

  • Memorial Sloan Kettering

    New York, New York, 10065, United States

  • Peter MacCallum Cancer Centre

    Melbourne, 3000, Australia

  • Prince of Wales Hospital

    Randwick, 2031, Australia

  • START Midwest

    Grand Rapids, Michigan, 49546, United States

  • Sapporo Hokuyu Hospital

    Hokkaido, 003-0006, Japan

  • The University of Kansas

    Fairway, Kansas, 66205, United States

  • Tokyo Metropolitan Cancer and Infectious Diseases Center Komagome Hospital

    Tokyo, 113-8677, Japan

  • Universitätsklinikum Ulm

    Ulm, 89081, Germany