Precision radiation may boost transplant success in tough leukemia cases
NCT ID NCT07532824
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a precise type of radiation called proton total marrow irradiation (TMI) given before a stem cell transplant for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see if adding TMI to standard chemotherapy is safe and helps reduce side effects. Sixteen adults will receive the treatment and be followed for two years.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
Proton total marrow irradiation (a type of radiation therapy)
What this could lead to
If successful, this approach could make stem cell transplants safer and more effective for people with hard-to-treat blood cancers.
What could go wrong
This is an early-phase trial with only 16 participants, so results may not apply broadly. There are risks of side effects from radiation and transplant complications.
Disclaimer
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This is a summary of
the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Institute of Hematology and Blood Transfusion
RECRUITINGPrague, 12800, Czechia
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Proton Therapy Center Czech
RECRUITINGPrague, 18000, Czechia
Contact Email: •••••@•••••