Precision radiation may boost transplant success in tough leukemia cases

NCT ID NCT07532824

Recruiting now Disease control Sponsor: Institute of Hematology and Blood Transfusion, Czech Republic Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tests a precise type of radiation called proton total marrow irradiation (TMI) given before a stem cell transplant for people with high-risk acute myeloid leukemia (AML) or myelodysplastic syndrome (MDS). The goal is to see if adding TMI to standard chemotherapy is safe and helps reduce side effects. Sixteen adults will receive the treatment and be followed for two years.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Proton total marrow irradiation (a type of radiation therapy)
What this could lead to: If successful, this approach could make stem cell transplants safer and more effective for people with hard-to-treat blood cancers.
What could go wrong: This is an early-phase trial with only 16 participants, so results may not apply broadly. There are risks of side effects from radiation and transplant complications.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia myelodysplastic syndrome myelodysplastic syndrome with excess blasts Myelodysplastic Syndromes therapy related acute myeloid leukemia and myelodysplastic syndrome

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA (AML) MDS AND AML PRIOR TO ALLOGENEIC SCT MYELODYSPLASTIC NEOPLASM MYELODYSPLASTIC SYNDROME (MDS)/AML PROTON THERAPY

Contacts and locations

Locations

Institute of Hematology and Blood Transfusion
RECRUITING

Prague, 12800, Czechia
Proton Therapy Center Czech
RECRUITING

Prague, 18000, Czechia

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