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Experimental drug for tough leukemias hits dead end

NCT ID NCT03922100

Terminated Disease control Sponsor: Nerviano Medical Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This early-phase trial tested an oral drug called NMS-03592088 in 63 adults with acute myeloid leukemia (AML) or chronic myelomonocytic leukemia (CMML) that had come back or not responded to standard treatments. The goal was to check safety, find the right dose, and see if it could shrink the cancer. The study was terminated early, so results are limited.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
NMS-03592088 (a targeted drug that blocks FLT3, KIT, and CSF1R proteins)
What this could lead to
If it had worked, this drug could have offered a new treatment option for people with hard-to-treat AML or CMML.
What could go wrong
The trial was terminated early, so we don't know if the drug is safe or effective. It was a small, early-phase study, and many such drugs fail to show benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute myeloid leukemia chronic myelomonocytic leukemia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE MYELOID LEUKEMIA (AML) CHRONIC MYELOMONOCYTIC LEUKEMIA (CMML)

Contacts and locations

Locations

  • ASST Grande Ospedale Metropolitano Niguarda

    Milan, MI, 20162, Italy

  • ASST Papa Giovanni XXIII

    Bergamo, BG, 24127, Italy

  • ASST Spedali Civili di Brescia

    Brescia, 25123, Italy

  • Azienda Ospedaliero-Universitaria di Bologna - Policlinico S.Orsola-Malpighi

    Bologna, 40138, Italy

  • CHU Hopitaux de Bordeaux - Hôpital Haut-Lévêque

    Pessac, 33604, France

  • Centre Hospitalier Lyon-Sud

    Pierre-Bénite, 69495, France

  • Centre Hospitalier Universitaire de Nantes (CHU de Nantes) - Hotel-Dieu

    Nantes, 44000, France

  • Centre Hospitalier du Mans

    Le Mans, 72037, France

  • Fondazione Policlinico Universitario Agostino Gemelli

    Roma, 00168, Italy

  • Hospital Universitari i Politècnic La Fe

    Valencia, 46026, Spain

  • Istituto Clinico Humanitas

    Rozzano, MI, 20089, Italy

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