New melanoma drug aims to match Keytruda's success
NCT ID NCT06320353
First seen Jul 15, 2026 · Last updated Jul 16, 2026 · Updated 1 time
Summary
This phase 3 trial compares a new drug, RPH-075, to the established immunotherapy Keytruda (both are forms of pembrolizumab) in people with advanced or spreading skin melanoma that cannot be surgically removed. The study aims to see if RPH-075 is as effective as Keytruda at shrinking tumors over 24 weeks. Participants receive either RPH-075 or Keytruda as their first or second treatment, and researchers monitor tumor response and side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- a drug called RPH-075, which is a version of pembrolizumab
- What this could lead to
- If successful, this could provide an equally effective but potentially more accessible treatment option for people with advanced melanoma.
- What could go wrong
- This is a comparison study, not a test of a new mechanism, so it may not offer any advantage over the existing drug. The trial is still recruiting and results are not yet known.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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"Euro Cityclinic" LLC
Saint Petersburg, 197022, Russia
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"Moscow Center for Rehabilitation Treatment" LLC
Moscow, 121552, Russia
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"Research lab" LLC
Moscow, 127521, Russia
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Branch Office of "Hadassah Medical Ltd"
Moscow, 121205, Russia
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Budgetary Healthcare Institution of the Udmurt Republic "Sergey Grigoryevich Primushko Republican Clinical Oncological Dispensary of the Ministry of Health of the Udmurt Republic"
Izhevsk, Udmurt Republic, 426009, Russia
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Budgetary healthcare institution of the Omsk region "Clinical Oncological Dispensary"
Omsk, 644013, Russia
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Federal State Autonomous Education Insitution of High Education the First Moscow State Medical University named after I.M. Sechenov of Ministry of Healthcare of Russian Federation (Sechenov University)
Moscow, 119991, Russia
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Federal State Budgetary Institution "N.N. Blokhin National Medical Research Center of Oncology" of the Ministry of Health of the Russian Federation
Moscow, 115478, Russia
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Federal State Budgetary Institution "National Medical Research Center of Radiology" of the Ministry of Health of the Russian Federation
Obninsk, Kaluga Oblast, 249036, Russia
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Kaluga Region State Budgetary Healthcare Institution "Kaluga Regional Clinical Oncological Dispensary"
Kaluga, 248007, Russia
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Medsi Group of Companies JSC
Moscow, 123056, Russia
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Private healthcare institution "Clinical Hospital "Russian Railways-Medicine" of the city of St. Petersburg"
Saint Petersburg, 195271, Russia
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Regional Budgetary Healthcare Institution "Kursk Oncological Research and Clinical Center named after G.E. Ostroverkhov"
Kislino, Kursk Oblast, 305524, Russia
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Regional State Budgetary Healthcare Institution "Krasnoyarsk Regional Clinical Oncological Dispensary named after A.I. Kryzhanovsky"
Krasnoyarsk, 660133, Russia
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Regional State Budgetary Healthcare Institution "Smolensk Regional Oncological Clinical Dispensary"
Smolensk, 214000, Russia
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Regional budgetary healthcare institution "Ivanovo Regional Oncological Dispensary"
Ivanovo, 153040, Russia
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Siberian State Medical University of the Ministry of Healthcare of Russian Federation
Tomsk, 634050, Russia
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St. Petersburg State Budgetary Healthcare Institution "City Clinical Oncological Dispensary"
Saint Petersburg, 197022, Russia
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State Autonomous Healthcare Institution "Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Tatarstan named after Professor M.Z.Segal"
Kazan', The Republic of Tatarstan, 420029, Russia
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State Autonomous Healthcare Institution Republican Clinical Oncological Dispensary of the Ministry of Health of the Republic of Bashkortostan
Ufa, The Republic of Bashkortostan, 450054, Russia
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State Budgetary Healthcare Institution "Clinical Oncological Dispensary No. 1" of the Ministry of Health of the Krasnodar Territory
Krasnodar, Krasnodar Territory, 350040, Russia
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State Budgetary Healthcare Institution "Regional Oncological Dispensary"
Irkutsk, 664035, Russia
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State Budgetary Healthcare Institution "Samara Regional Clinical Oncological Dispensary"
Samara, 443031, Russia
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State Budgetary Healthcare Institution Leningrad Regional Clinical Hospital
Saint Petersburg, 188300, Russia
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State Budgetary Healthcare Institution of the Arkhangelsk region "Arkhangelsk Clinical Oncological Dispensary"
Arkhangelsk, 163045, Russia
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State Budgetary Healthcare Institution of the Nizhny Novgorod region "Nizhny Novgorod Regional Clinical Oncological Dispensary"
Nizhny Novgorod, 603126, Russia
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State Budgetary Healthcare Institution of the Novosibirsk region "Novosibirsk Regional Clinical Oncological Dispensary"
Novosibirsk, 630108, Russia
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State Budgetary Healthcare Institution of the Perm Territory "Perm Regional Oncological Dispensary"
Perm, 614066, Russia
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State Budgetary Healthcare Institution of the city of Moscow "City Clinical Oncological Hospital No. 1 of the Department of Health of the City of Moscow"
Moscow, 117152, Russia
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State Budgetary Healthcare Institution of the city of Moscow "Moscow City Oncological Hospital No. 62 of the Department of Health of the City of Moscow"
Istra, Moscow Oblast, 143515, Russia
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State Budgetary Institution of healthcare of the city of Moscow "Moscow Multidisciplinary Clinical Center "Kommunarka" of the Department of Healthcare of the City of Moscow"
Moscow, 108814, Russia
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State Budgetary healthcare Institution "Kuzbass Clinical Oncological Dispensary named after M.S. Rappoport"
Kemerovo, 650036, Russia
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State Healthcare Institution "Regional Clinical Oncological Dispensary"
Saratov, 410053, Russia
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The State Autonomous Healthcare Institution of the Sverdlovsk region "Sverdlovsk Regional Oncological Dispensary"
Yekaterinburg, Sverdlovsk Oblast, 620036, Russia
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The State Autonomous healthcare Institution of the Tyumen region "Multidisciplinary clinical Medical Center "Medical City"
Tyumen, 625041, Russia
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The State budgetary healthcare Institution of the Stavropol Territory "Pyatigorsk Interdistrict Oncological Dispensary"
Pyatigorsk, Stavropol Territory, 357502, Russia
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