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New drug combo shows promise for rare blood cancer in early trial

NCT ID NCT02223208

Ongoing Disease control Sponsor: Fondazione Italiana Linfomi - ETS Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests adding the drug romidepsin to standard chemotherapy (CHOEP) for young adults (ages 18-65) with a rare type of lymphoma called peripheral T-cell lymphoma. The goal is to see if this combination is safe and effective before patients undergo a stem cell transplant. About 89 participants will be enrolled to find the best dose and measure how long they stay cancer-free.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance

Romidepsin combined with chemotherapy (cyclophosphamide, doxorubicin, vincristine, etoposide, prednisone)

What this could lead to

If successful, this could lead to a more effective treatment strategy for young patients with peripheral T-cell lymphoma, potentially improving remission rates before stem cell transplant.

What could go wrong

This is an early-phase trial (Phase I/II) with a small number of participants, so results may not apply broadly. The combination may cause significant side effects, and the added benefit of romidepsin is not yet proven.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Conditions

The condition(s) this trial relates to.

ALK-negative anaplastic large cell lymphoma ALK-positive anaplastic large cell lymphoma angioimmunoblastic T-cell lymphoma mature T-cell and NK-cell non-Hodgkin lymphoma Nodal T-follicular helper cell lymphoma, follicular type peripheral T-cell lymphoma, not otherwise specified

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ALK- ANAPLASTIC LARGE CELL LYMPHOMA (ALCL) ANGIOIMMUNOBLASTIC T-CELL LYMPHOMA (AITL) NODAL PERIPHERAL T-CELL LYMPHOMA OF T FOLLICULAR HELPER CELL ORIGIN PERIPHERAL T-CELL LYMPHOMAS (PTCL) PTCL-NOS

Contacts and locations

Locations

  • A.O. di Perugia - Santa Maria della Misericordia

    Perugia, 06132, Italy

  • AO Città della Salute e della Scienza - Ematologia 1U

    Torino, TO, 10126, Italy

  • AO Città della Salute e della Scienza - SC Ematologia

    Torino, TO, 10126, Italy

  • AO Ospedali Riuniti Villa Sofia - Cervello (Presidio Cervello)

    Palermo, PA, 90146, Italy

  • AOU "Santa Maria della Misericordia"

    Udine, UD, 33100, Italy

  • AOU di Parma

    Parma, PR, 43100, Italy

  • Azienda Ospedaliera Ospedale Niguarda Ca' Granda

    Milan, MI, 20162, Italy

  • Azienda Ospedaliera S.Croce e Carle

    Cuneo, CN, 12100, Italy

  • Fondazione IRCCS "Istituto Nazionale dei Tumori"

    Milan, MI, 20133, Italy

  • Fondazione IRCCS - Policlinico San Matteo

    Pavia, PV, 27100, Italy

  • Fondazione IRCCS Ca' Granda Ospedale Maggiore Policlinico

    Milan, MI, 20122, Italy

  • IRCCS AOU San Martino - Clinica Ematologica

    Genova, GE, 16321, Italy

  • IRCCS AOU San Martino - UO Ematologia 1

    Genova, GE, 16321, Italy

  • IRCCS Arcispedale "Santa Maria Nuova"

    Reggio Emilia, RE, 42123, Italy

  • IRCCS Centro di Riferimento Oncologico (CRO)

    Aviano, PN, 33081, Italy

  • Istituto Clinico Humanitas

    Rozzano, Milano, 20089, Italy

  • Istituto Nazionale Tumori IRCCS - Fondazione G. Pascale

    Naples, 80131, Italy

  • Istituto Scientifico Romagnolo per lo Studio e la Cura dei Tumori (I.R.S.T.) - Sede di Meldola

    Meldola, FC, 47014, Italy

  • Ospedale Borgo Roma

    Verona, VR, 37134, Italy

  • Ospedale Businco

    Cagliari, CA, 09121, Italy

  • Ospedale G. Da Saliceto - AUSL di Piacenza

    Piacenza, 29121, Italy

  • Ospedale Maggiore della Carità - SCDU Ematologia

    Novara, 28100, Italy

  • Ospedale SS. Antonio e Biagio e Cesare Arrigo

    Alessandria, AL, 15121, Italy

  • Ospedale degli Infermi

    Rimini, RN, 47900, Italy

  • Policlinico S. Orsola Malpighi

    Bologna, BO, 40138, Italy

  • Spedali Civili

    Brescia, BS, 26123, Italy

  • UO Ematologia Ospedale S.Maria delle Croci

    Ravenna, 48121, Italy