Can a Two-Drug combo outsmart Hard-to-Treat lymphoma?

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: 1. Age 18 years or older, both males and females are eligible; 2. Histologically confirmed peripheral T-cell lymphoma (PTCL) including PTCL-NOS and TFHL that has relapsed or is refractory after at least one line of systemic therapy. The definitions are as follows: Relapse: Patients who achieved a Complete Response (CR) in previous treatments and have new lesions at the original site or elsewhere; Refractory: Patients who did not achieve CR after adequate treatment. For nasal-type NK/T-cell lymphoma, previous treatments must have included a chemotherapy regimen containing asparaginase; 3. Patients who have undergone prior hematopoietic stem cell transplantation are allowed; 4. ECOG PS 0-2 5. Life expectancy greater than 3 months. 6. Adequate organ function 7. Contraception during study 8. Informed consented Exclusion Criteria: 1. Prior treatment with EZH2 inhibitors or EZH1/2 inhibitors before enrollment; 2. Peripheral T-cell lymphoma of subtypes other than PTCL-NOS and TFHL; 3. History of other primary invasive malignancies that have not been in remission or have been in remission for no more than 3 years; 4. Central nervous system involvement (meningeal or parenchymal); 5. Known hypersensitivity to any study drugs; 6. Participation in another clinical trial of an investigational drug within 4 weeks prior to the start of the study. 7. Pregnant or lactation 8. Active infection. 9. Diseases and medical history: 1. Requires continuous treatment with strong or moderate CYP3A inhibitors or CYP3A inducers 2. Has multiple factors affecting oral medication administration (e.g., inability to swallow, chronic diarrhea, intestinal obstruction, etc.); 3. Has a history of psychoactive substance abuse that cannot be discontinued 4. Has any severe and/or uncontrolled disease. 10. Uncontrollable autoimmune disease, 11. Not able to comply to the protocol for mental or other unknown reasons 12. Any other condition that, in the investigator's judgment, makes the patient unsuitable for study participation.