RNA vaccine fights childhood cancers in new trial
NCT ID NCT05660408
First seen Jun 27, 2026 · Last updated Jun 27, 2026
Summary
This study tests a new RNA-lipid particle vaccine for children and young adults (ages 3-25) with recurrent high-grade glioma or osteosarcoma that has spread to the lungs. The vaccine is made from the patient's own tumor material and aims to train the immune system to attack the cancer. The trial will check safety, the right dose, and whether the vaccine activates immune cells.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
RNA-lipid particle vaccine (personalized from the patient's tumor)
What this could lead to
If it works, this could point toward a new treatment option for children with hard-to-treat brain tumors or bone cancer that has come back.
What could go wrong
This is an early-phase trial with only 36 participants, so it is too small to prove effectiveness. The vaccine may not work for everyone, and there could be side effects from the immune response.
Disclaimer
Read more
Show less
This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for RECURRENT HIGH GRADE GLIOMA are added.
By submitting, you agree to our Terms of use
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Show contact details
Enter your email to view the contact information for this study.
By submitting, you agree to our Terms of use
Locations
-
UF Health
Gainesville, Florida, 32608, United States