New hope for hard-to-treat melanoma: drug combo targets resistant tumors

NCT ID NCT05764395

First seen Apr 29, 2026 · Last updated Jun 11, 2026 · Updated 11 times

Summary

This study tests whether adding rigosertib to pembrolizumab can help people with advanced melanoma that did not respond to previous immunotherapy. Rigosertib may block cancer cell growth and make the immune system more responsive to pembrolizumab. The trial enrolled 7 adults with unresectable or metastatic melanoma. The main goal is to see how many patients' tumors shrink or stop growing.

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Contacts and locations

Locations

  • Vanderbilt University/Ingram Cancer Center

    Nashville, Tennessee, 37232, United States

Conditions

Explore the condition pages connected to this study.