New hope for kids with relapsed leukemia: early trial combines three drugs

NCT ID NCT03740334

Ongoing Disease control Sponsor: Dana-Farber Cancer Institute Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This early-phase trial tests a combination of three drugs—ribociclib, everolimus, and dexamethasone—in children and young adults (ages 1 to 30) whose acute lymphoblastic leukemia has come back or not responded to standard treatment. The main goal is to find the safest dose and understand how the drugs move through the body. Up to 45 participants will be enrolled.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: ribociclib, everolimus, and dexamethasone
What this could lead to: If it works, this could point toward a new treatment option for children and young adults with relapsed acute lymphoblastic leukemia.
What could go wrong: This is a very early phase 1 trial with only 45 participants, focused on finding a safe dose. It is too small to prove effectiveness, and the drugs may cause significant side effects.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

acute lymphoblastic leukemia blast phase chronic myelogenous leukemia, BCR-ABL1 positive Precursor Cell Lymphoblastic Leukemia-Lymphoma

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

ACUTE LYMPHOBLASTIC LEUKEMIA (ALL)

Contacts and locations

Locations

Boston Children's Hospital

Boston, Massachusetts, 02115, United States
Children's Healthcare of Atlanta

Atlanta, Georgia, 30322, United States
Children's Hospital Colorado

Aurora, Colorado, 80045, United States
Children's Hospital of Philadelphia

Philadelphia, Pennsylvania, 19104, United States
Children's Hospital of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Cincinnati Children's Hospital Medical Center

Cincinnati, Ohio, 45229, United States
Dana Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Dana-Farber Cancer Institute

Boston, Massachusetts, 02215, United States
Memorial Sloan Kettering Cancer Center

New York, New York, 10174, United States
Nemours/Alfred I. duPont Hospital for Children

Wilmington, Delaware, 19803, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Texas Children's Hospital

Houston, Texas, 77030, United States

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