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Which heat treatment shrinks thyroid nodules better?

NCT ID NCT07804862

Disease control Sponsor: The University of Hong Kong Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now This study
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Sep 04, 2026 · Last updated Sep 04, 2026

Summary

This trial compares two minimally invasive procedures, radiofrequency ablation (RFA) and microwave ablation (MWA), for treating large benign thyroid nodules. Adults with a single nodule of at least 20 milliliters will be randomly assigned to one of the two heat-based treatments. The study measures how much the nodule shrinks at 6 and 12 months, along with any complications. The goal is to find which method offers better shrinkage and safety, potentially offering a non-surgical option for people with pressure symptoms.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Radiofrequency ablation (RFA) or microwave ablation (MWA), both heat-based procedures that use image guidance to destroy thyroid nodule tissue.
What this could lead to
If one method proves safer or more effective, it could become the preferred non-surgical option for shrinking large benign thyroid nodules and easing pressure symptoms.
What could go wrong
This is a small, early-stage trial with only 25 participants, so results may not apply broadly. Both procedures carry risks like vocal cord palsy, bleeding, infection, or skin burn.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 25 people

The number the study aims to enrol. It can still change while the study runs.

Started

Dec 2023

Expected to finish

Jun 2027

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * who have a solitary thyroid nodule ≥20ml in volume * two benign fine needle biopsies, with the most recent biopsy performed within 1 year of enrollment in study or one benign fine needle biopsy and low suspicion characteristics on ultrasound * Both functional and non-functional nodules are eligible Exclusion Criteria: * have multiple nodules and planned simultaneous ablation * indeterminate nodules classified benign * nodules with substernal extension or posterior extension that cannot be viewed sufficiently with ultrasound * current pregnancy or cardiac arrhythmias

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Conditions

The condition(s) this trial relates to.

benign thyroid gland neoplasm

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Ablation techniques, rfa Ablation treatment Benign thyroid nodules Local anaesthesia

How to take part

Only the study team decides who joins. These are the ways to reach them.

  1. The places running it

    1 site. The list below names each one and where it is.

  2. The official record

    ClinicalTrials.gov lists the study team's own contact details, including names and phone numbers. We don't republish those.

    Open the record ↗

  3. A doctor treating you

    A doctor who knows your case can contact a study site on your behalf, and can tell you whether this study is worth pursuing at all.

Contacts and locations

Locations

  • Queen Mary Hospital

    RECRUITING

    Hong Kong, Hong Kong

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