Routine heart scans after stents: could they save lives?

NCT ID NCT05923489

Recruiting now Knowledge-focused Sponsor: Second Affiliated Hospital, Zhejiang University, School of Medicine Source: ClinicalTrials.gov ↗

This trial is taking on new participants right now.

First seen Aug 21, 2026 · Last updated Aug 21, 2026

Summary

This trial asks whether high-risk patients who receive a stent for coronary artery disease benefit from a routine angiography scan about a year later, compared to usual clinical follow-up without routine imaging. The study enrolls adults who had successful stent placement and have at least two high-risk features, such as complex blockages or multiple vessels treated. Researchers will compare rates of death, heart attack, or hospitalization for unstable angina between the two follow-up strategies.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Routine angiography follow-up (a diagnostic imaging procedure) versus routine clinical follow-up
What this could lead to: If routine angiography after stent placement proves better than standard check-ups, it could become a new standard for monitoring high-risk heart patients, potentially reducing deaths, heart attacks, and hospitalizations.
What could go wrong: The trial is large but not randomized, and routine angiography carries risks like contrast-related kidney injury or procedure complications. It may also lead to unnecessary interventions without clear benefit.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 2,618 people

The number the study aims to enrol. It can still change while the study runs.

Started

Oct 2023

Expected to finish

Oct 2029

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 years and older

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age ≥ 18 years. * Successful PCI with at least two of the following high-risk factors: A. Left main lesion; B. Bifurcation lesion (true bifurcation); C. Ostial lesion of main vessels (left anterior descending, left circumflex artery, right coronary artery); D. Chronic total occlusion; E. Multivessel revascularization (≥ 2 vessels); F. In-stent restenosis; G. Diffuse long lesion (lesion length ≥ 30 mm or stent length ≥ 38 mm); H. Severe calcified lesion (Significant severe calcification on angiography); I. Bypass graft lesion; J. Diabetes mellitus; K. Chronic kidney disease (defined as an estimated glomerular filtration rate of \<30 ml per minute per 1.73 m2 of body-surface area or the receipt of dialysis); L. Myocardial infarction; \- He/she or his/her legally authorized representative provides written informed Exclusion Criteria: * Revascularization with bare metal stents and/or balloon angioplasty with non-drug-coated balloons. * Pregnant and/or lactating women. * Life expectancy of less than 2 years. * Repeat interventional therapy is planned. * Subject was unable to provide written informed consent.

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Conditions

The condition(s) this trial relates to.

coronary artery disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CORONARY ARTERY DISEASE

Contacts and locations

Locations

The Second Affiliated Hospital of Zhejiang University School of Medicine
RECRUITING

Hangzhou, Zhejiang, 310009, China

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