Can a second workout cause less muscle damage? new study investigates.

NCT ID NCT07503860

Ongoing Knowledge-focused Sponsor: Vassilis Paschalis Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 2 times

Summary

This study looks at how the body's markers of muscle damage change after a tough leg workout, and whether doing the same workout again causes less damage (the 'repeated bout effect'). 48 healthy, active men will do eccentric knee exercises on a machine. Researchers will measure pain, strength, movement, oxygen levels, and blood markers before and two days after exercise.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Eccentric exercise (maximal voluntary contractions on an isokinetic dynamometer)
What this could lead to: If successful, this could help design better exercise programs to reduce muscle soreness and injury risk.
What could go wrong: This is a small, early-stage observational study in healthy males only. Results may not apply to women, older adults, or people with health conditions.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EXERCISE-INDUCED MUSCLE DAMAGE

Contacts and locations

Locations

Department of Physical Education and Sport Science, National and Kapodistrian University of Athens

Athens, Attica, 17237, Greece

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