New trial aims to save rectums in rectal cancer patients
NCT ID NCT06952101
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This study tests a personalized, stage-based approach to treat rectal cancer while trying to avoid removing the rectum. 200 participants will receive either experimental chemoradiotherapy or minimally invasive surgery depending on their cancer stage. The goal is to preserve the rectum and improve quality of life without compromising cancer control.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- chemoradiotherapy (experimental and standard), minimally invasive surgery (laparoscopic/robotic)
- What this could lead to
- If successful, this could offer a way to treat rectal cancer without removing the rectum, preserving bowel function and quality of life for many patients.
- What could go wrong
- This is an early-phase study with only 200 participants, so results may not apply to everyone. The organ-sparing approach may not work for all patients, and some may still need surgery or face cancer recurrence.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Department of Surgical Oncology - FPO-IRCCS Institute for Cancer Research and Treatment
RECRUITINGCandiolo, Turin, 10060, Italy
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- AI as a surgical Co-Pilot: predicting difficulty in rectal cancer
- A new radiation combo may spare the rectum in early cancer
- Can a triple-drug cocktail after short radiation eliminate rectal cancer without surgery?
- Metabolic MRI may reveal hidden cancer responses and spare patients from surgery
- Can a beetroot drink spot dangerous surgical leaks before they turn deadly?