New hope to slow deadly lung disease progression

NCT ID NCT03626688

Summary

This study tested whether adding a new drug called ralinepag to standard treatments could help people with pulmonary arterial hypertension (PAH), a serious lung and heart condition. It involved 687 adults with PAH who were already on stable medication. The main goal was to see if ralinepag could delay events like hospitalization or disease worsening compared to a placebo.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

Locations

  • "Onasseio" Cardiosurgery Hospital, Hemodynamic Research and Interventional Cardiology Dept., 356, Syggrou Avenue

    Athens, Kallithea, 17674, Greece

  • AHEPA General Hospital of Thessaloniki, A' Cardiology Clinic, 1 St. Kyriakidi Street

    Thessaloniki, 54636, Greece

  • AKH Wien, Innere Med. II, Kardiologie, Währingergürtel 18-20

    Vienna, 1090, Austria

  • Allegheny General Hospital

    Pittsburgh, Pennsylvania, 15212, United States

  • Ascension Alexian Brothers

    Elk Grove Village, Illinois, 60007, United States

  • Ascension Texas Cardiovascular

    Austin, Texas, 78705, United States

  • Azienda Ospedaliera Universitaria Policlinico Umberto I - Università di Roma La Sapienza, Viale del Policlinico, 155

    Roma, Roma, 00161, Italy

  • Azienda Ospedaliero Universitaria Ospedali Riuniti di Foggia, S.C. di Cardiologia, Viale Luigi Pinto, 1

    Foggia, Foggia, 71100, Italy

  • Azienda Socio Sanitaria Territoriale di Monza (Presidio San Gerardo)

    Monza, 20900, Italy

  • Balcalı, Çukurova Üniversitesi Kardiyoloji ABD

    Adana, Saricam, 01330, Turkey (Türkiye)

  • Baylor University Medical Center

    Dallas, Texas, 75246, United States

  • Beijing Shijitan Hospital, Capital Medical University

    Beijing, Beijing Municipality, 100038, China

  • Boston University Medical Center

    Boston, Massachusetts, 02118, United States

  • CE Dniprop RCC&C Center of Dniprop RC Dept of Card SI DMA of MOHU, Chair of Internal Medicine 3, 28, Knyazya Volodymyra Velykogo St.

    Dnipro, 49070, Ukraine

  • CHRU de Lille - Hopital Cardiologique

    Lille, 59037, France

  • CHU Besançon - Hôpital Jean Minjoz

    Besançon, 25030, France

  • CHU Lyon - Hôpital Cardio-Vasculaire et Pneumologique Louis Pradel, Service de Pneumologie, 59 Boulevard Pinel

    Bron, Rhone, 69677, France

  • CHU Nancy - Hôpital de Brabois Adultes, Pneumologie- Oncologie Médicale, Rue du Morvan

    Vandœuvre-lès-Nancy, Meurthe et Moselle, 54511, France

  • CHU de Brest - Hôpital de la Cavale Blanche

    Brest, 29609, France

  • CHU de Grenoble - Hôpital Albert Michallon, Clinique de Cardiologie, Boulevrad de la Chantourne

    Grenoble, Isere, 38048, France

  • CHU de Rouen - Hôpital Charles Nicolle

    Rouen, Seine Maritime, 76031, France

  • CHU de Saint-Etienne - Hopital Nord, Service de Medecine vasculaire et therapeutique, 81 Avenue A. Raimond

    Saint-Étienne-de-Montluc, Pays de la Loire Region, 42005, France

  • CHU de Strasbourg - Nouvel Hôpital Civil, Ctre de competence Hypertension Arterielle Pulmona, 1 place de l Hopital

    Strasbourg, Bas Rhin, 67091, France

  • CICUM San Miguel

    Guadalajara, Jalisco, 44160, Mexico

  • Cardiologia Palmero

    Caba, Buenos Aires F.D., 1425, Argentina

  • Carilion Clinic Pulmonary and Sleep Medicine

    Roanoke, Virginia, 24014, United States

  • Cedars-Sinai Medical Center

    Los Angeles, California, 90048, United States

  • Central Florida Pulmonary Group

    Orlando, Florida, 32803, United States

  • Centro Hospitalar Universitário Lisboa Norte, E.P.E. Hospital Pulido Valente

    Lisbon, 1769-001, Portugal

  • Centro Hospitalar de Santo António E.P.E.

    Porto, Porto District, 4099-001, Portugal

  • Centro Hospitalar e Universitário de Coimbra, E.P.E.

    Coimbra, 3000-075, Portugal

  • Chest Medicine Associates

    South Portland, Maine, 04106, United States

  • Cleveland Clinic

    Cleveland, Ohio, 44195, United States

  • Cleveland Clinic Florida

    Weston, Florida, 33331, United States

  • Clinical Center Zemun. Clinic for internal medicine, Department of Cardiology

    Belgrade, 11080, Serbia

  • Clinical Center of Serbia, Koste Todorovica 8

    Belgrade, 11000, Serbia

  • Clinical Hospital Dubrava Zagreb, Avenija G.Šuška 6

    Zagreb, 10000, Croatia

  • Cliniques Universitaires de Bruxelles Hopital Erasme

    Brussels, 1070, Belgium

  • Communal Noncommercial Enterprise of Lviv Regional Council Lviv Clinical Hospital, Dept of Cardiology, D.Halytskyi Lviv NMU, Ch of Internal Medicine #1, 7, Chernihivska str.

    Lviv, 79010, Ukraine

  • Community Health Network Cancer Center North

    Indianapolis, Indiana, 46250, United States

  • Copenhagen University Hospital (Rigshospitalet)

    Copenhagen, 2100, Denmark

  • Dokuz Eylul Universitesi Tip Fakultesi, Mithatpasa caddesi Inciralti Balcova

    Izmir, 35340, Turkey (Türkiye)

  • Duke University Medical Center

    Durham, North Carolina, 27710, United States

  • East Carolina University

    Greenville, North Carolina, 27834, United States

  • Emory University Hospital

    Atlanta, Georgia, 30322, United States

  • Fiona Stanley Hospital

    Murdoch, Western Australia, 6150, Australia

  • Fondazione IRCCS CA' Granda Ospedale Maggiore Policlinico, Via Francesco Sforza 35

    Milan, 20122, Italy

  • Fondazione IRCCS Policlinico San Matteo

    Pavia, 27100, Italy

  • Fundacion Favaloro

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires, C1093AAS, Argentina

  • Fundacion Respirar

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires, 1426, Argentina

  • Fuwai Hospital, Chinese Academy of Medical Sciences

    Beijing, 100037, China

  • Gachon University Hospital Gil Medical Center

    Incheon, Namdong-gu, 21565, South Korea

  • Gazi University Medical Faculty Hospital

    Ankara, 06560, Turkey (Türkiye)

  • Golden Jubilee National Hospital

    Glasgow, West Dunbartonshire, G81 4DY, United Kingdom

  • Gottsegen György Országos Kardiovaszkuláris Intézet

    Budapest, Budapest, 1096, Hungary

  • Groupement Hospitalier Sud - Hôpital Bicêtre

    Le Kremlin-Bicêtre, Val de Marne, 94275, France

  • Guangdong Provincial People's Hospital

    Guangzhou, Guangdong, 510080, China

  • HC-UFG - Hospital das Clínicas da Universidade Federal de Goiás

    Goiânia, Goiás, 74605-020, Brazil

  • Hadassah Ein Kerem Medical Center, Kiryat Hadassah

    Jerusalem, 9112001, Israel

  • Hospital Britanico de Buenos Aires

    Ciudad Autonoma Buenos Aires, Ciudad Autonoma Buenos Aires, 1280, Argentina

  • Hospital Clinic de Barcelona, C/ Villarroel, 170

    Barcelona, 08036, Spain

  • Hospital Garcia de Orta, E.P.E

    Almada, 2805-267, Portugal

  • Hospital Italiano

    Ciudad Autonoma Buenos Aires, Buenos Aires, C1181ACH, Argentina

  • Hospital Italiano de Cordoba

    Córdoba, X5004BAL, Argentina

  • Hospital PROVINCIAL "Dr. Jose Maria Cullen"

    Santa Fe, Santa Fe Province, 3000, Argentina

  • Hospital Privado Centro Medico de Cordoba S.A

    Córdoba, Córdoba Province, X5016KEH, Argentina

  • Hospital Sao Lucas da PUC-RS

    Porto Alegre, R.S, 90610-000, Brazil

  • Hospital Sao Paulo

    São Paulo, São Paulo, 04037-002, Brazil

  • Hospital Universitari Vall d'Hebron, Respiratory Dept., Passeig Vall d'Hebron,119-129, Neumologia

    Barcelona, 08035, Spain

  • Hospital Universitario 12 de Octubre

    Madrid, Madrid, 28041, Spain

  • Hospoital Universitari i Politecnic La Fe

    Valencia, Valencia, 46026, Spain

  • Hôpital Nord - CHU Marseille

    Marseille, 13015, France

  • IRCC Ospedale Policlinico San Martino

    Genova, Genova, 16132, Italy

  • Imperial College Healthcare NHS Trust

    London, W12 0HS, United Kingdom

  • Indiana University School of Medicine

    Indianapolis, Indiana, 46202, United States

  • Institut Universitaire de Cardiologie et de Pneumologie de Quebec

    Québec, Quebec, G1V 4G5, Canada

  • Institute for Pulmonary Diseases of Vojvodina, Put Dr Goldmana 4

    Kamenitz, 21204, Serbia

  • Instituto Nacional de Cardiologia Dr Ignacio Chavez Rivera

    Mexico City, Mexico City, 14080, Mexico

  • Instituto Nacional de Ciencias Médicas y Nutricion Dr. Salvador Zubiran

    Mexico City, Mexico City, 14080, Mexico

  • Instituto das Pequenas Missionárias de Maria Imaculada - Hospital Madre Teresa

    Belo Horizonte, Minas Gerais, 30441-070, Brazil

  • Instituto de Cardiologia de Corrientes

    Corrientes, Corrientes Province, Argentina

  • Instituto de Investigaciones Clinicas Mar del Plata

    Mar del Plata, Buenos Aires, 7600, Argentina

  • Instituto do Coracao

    São Paulo, São Paulo, 05403-000, Brazil

  • Institutul Inimii "Niculae Stancioiu" Cluj-Napoca, Cardiologie, Str. Motilor nr. 19-21

    Cluj-Napoca, 400001, Romania

  • Institutul de Pneumoftiziologie "Marius Nasta", Sos. Viilor nr. 90, Sector 5

    Bucharest, 050159, Romania

  • Institutul de Urgenta pentru Boli Cardiovasculare "Prof. Dr. C.C. Iliescu", Sos. Fundeni nr. 258

    Bucharest, 022328, Romania

  • Instiuto Nacional del Torax

    Providencia, Santiago de Chile, 7500691, Chile

  • Integris Baptist Medical Center

    Oklahoma City, Oklahoma, 73112, United States

  • Irmandade da Santa Casa de Misericórdia de Porto Alegre

    Porto Alegre, Rio Grande do Sul, 90035-074, Brazil

  • Istituto Mediterraneo Trapianti e Terapie a Alta Specializzazione (IRCCS-ISMETT)

    Palermo, PA, 90127, Italy

  • Kaiser Permanente Los Angeles Medical Center

    Los Angeles, California, 90027, United States

  • Keck Hospital of USC

    Los Angeles, California, 90033, United States

  • Kentuckiana Pulmonary Research Center

    Louisville, Kentucky, 40202, United States

  • Krakowski Szpital Specjalistyczny im. Jana Pawla II, Oddział Kliniczny Chorób Serca i Naczyń z Pododdziałem Intensywnego Nadzoru Kardiologicznego, Pradnicka 80

    Krakow, 31-202, Poland

  • LA Biomedical Research Institute Harbor-UCLA Medical Center

    Torrance, California, 90502, United States

  • LHSC - Victoria Hospital

    London, Ontario, N6A 5W9, Canada

  • Linköping Universitetssjukhuset

    Linköping, 58185, Sweden

  • Loma Linda University Medical Center

    Loma Linda, California, 92354, United States

  • MHAT "Sveta Anna" Sofia AD

    Sofia, Sofia, 1750, Bulgaria

  • MHAT - "National Heart Hospital" EAD, 65, Konyovitza Str.

    Sofia, 1309, Bulgaria

  • Macquarie University

    Macquarie, New South Wales, 2109, Australia

  • Marmara Universitesi Istanbul Pendik Egitim ve Arastirma Hastanesi

    Istanbul, 34899, Turkey (Türkiye)

  • Massachusetts General Hospital

    Boston, Massachusetts, 02114, United States

  • Medical College of Wisconsin/Froedtert Hospital

    Milwaukee, Wisconsin, 53226, United States

  • Medizinische Universität Innsbruck

    Innsbruck, 6020, Austria

  • Meir Medical Center, 59 Tshernichovski st.

    Kfar Saba, 4428164, Israel

  • Memorial Hermann Hospital

    Houston, Texas, 77030, United States

  • Mersin Üniversitesi Tip Fakültesi Ciftlikköy Kampüsü

    Mersin, Yenisehir, 33343, Turkey (Türkiye)

  • Mount Sinai School of Medicine

    New York, New York, 10029, United States

  • NYU Langone Medical Center

    New York, New York, 10016, United States

  • NZOZ Europejskie Centrum Zdrowia, ul. Borowa 14/18

    Otwock, 05-400, Poland

  • National Cheng Kung University Hospital

    Tainan, 704, Taiwan

  • National Heart Centre

    Singapore, 169609, Singapore

  • National Jewish Health

    Denver, Colorado, 80206, United States

  • National Taiwan University Hospital

    Taipei, Taipei, 10002, Taiwan

  • National University Hospital

    Singapore, Singapore, 119074, Singapore

  • Nebraska Medical Center

    Omaha, Nebraska, 68198, United States

  • Nepean Hospital

    Kingswood, New South Wales, 2751, Australia

  • Norrlands Universitetssjukhus, Hjärtcentrum

    Umeå, 90185, Sweden

  • Ochsner Medical Center

    New Orleans, Louisiana, 70121, United States

  • Ordensklinikum Linz GmbH - Elisabethinen, Fadingerstrasse 1

    Linz, 4020, Austria

  • Oregon Clinic-Pulmonary West

    Portland, Oregon, 97225, United States

  • Oregon Health & Science University

    Portland, Oregon, 97239, United States

  • Osmangazi Uni Medical Faculty

    Eskişehir, Odunpazari, 26040, Turkey (Türkiye)

  • Pecsi Tudomanyegyetem, Szivgyogyaszati Klinika, Ifjusag u. 13.

    Pécs, 7624, Hungary

  • Peter Lougheed Centre

    Calgary, Alberta, T1Y 6J4, Canada

  • Piedmont Healthcare Pulmonary and Critical Care Research

    Austell, Georgia, 30106, United States

  • Premium Clinic Wrocław CM, Podwale 83/17

    Wroclaw, 50-414, Poland

  • Princess Alexandra Hospital

    Woolloongabba, Queensland, 4102, Australia

  • Rabin Medical Center-Beilinson Campus, Pulmonary Institute, 39 Jabotinsky St Ground floor

    Petah Tikva, 4941492, Israel

  • Ronald Reagan UCLA Medical Center

    Los Angeles, California, 90024, United States

  • Royal Brompton Hospital

    London, SW3 6NP, United Kingdom

  • Royal Free London NHS Foundation Trust, Pond Street

    London, Greater London, NW3 2QG, United Kingdom

  • Royal Hobart Hospital

    Hobart, Tasmania, 7000, Australia

  • Royal Prince Alfred Hospital

    Camperdown, New South Wales, 2050, Australia

  • SBPA Research LLC

    Santa Barbara, California, 93105, United States

  • SI F.H.Yanovskyi National Institute of Phthisiology and Pulmonology of NAMSU, Clinical and Functional Dept, 10, Amosova St.

    Kyiv, 03680, Ukraine

  • SMBD Jewish General Hospital d/b/a Jewish General Hospital

    Montreal, Quebec, H3T1E2, Canada

  • Sahlgrenska Universitetssjukhuset

    Gothenburg, 41345, Sweden

  • Samsung Medical Center

    Seoul, Gangnam-gu, 06351, South Korea

  • Sanatorio Parque

    Rosario, Santa Fe Province, 2000, Argentina

  • Sanatorio de la Trinidad Mitre

    Buenos Aires, Buenos Aires, C1039AAO, Argentina

  • Schwarzwald-Baar Klinikum

    Donaueschingen, 78166, Germany

  • Sentara Cardiovascular Research Institute

    Norfolk, Virginia, 23507, United States

  • Seoul National University Hospital

    Seoul, Jongno-gu, 03080, South Korea

  • Shanghai Pulmonary Hospital

    Shanghai, Shanghai Municipality, 200443, China

  • Spectrum Health Medical Group

    Grand Rapids, Michigan, 49546, United States

  • Spitalul Clinic de Boli Infectioase si Pneumoftiziologie "Dr. Victor Babes" Timisoara, Str. Gheorghe Adam nr. 13

    Timișoara, 300310, Romania

  • St Vincent's Hospital Melbourne

    Fitzroy, Victoria, 3065, Australia

  • St Vincent's Hospital Sydney

    Darlinghurst, New South Wales, 2010, Australia

  • St. Joseph's Hospital and Medical Center

    Phoenix, Arizona, 85013, United States

  • St. Vincent Medical Group, Inc.

    Indianapolis, Indiana, 46260, United States

  • Stanford Healthcare

    Stanford, California, 94305, United States

  • Statcare Pulmonary Consultants

    Knoxville, Tennessee, 37919, United States

  • Szegedi Tudományegyetem Szent-Györgyi Albert Klinikai Központ Családorvosi Intézet és Rendelő

    Szeged, Csongrád-Csanád, Hungary, Hungary

  • Szpital Kliniczny Przemienienia Panskiego Uniwersytetu Medycznego im. Karola Marcinkowskiego w Poznaniu, Oddzial Kardiologii - F, ul. Dluga 1/2

    Poznan, 61-848, Poland

  • Tel Aviv Sourasky Medical Center, 6 Weizmann St.

    Tel Aviv, 6423906, Israel

  • Temple University

    Philadelphia, Pennsylvania, 19140, United States

  • The Alfred Hospital

    Melbourne, Victoria, 3004, Australia

  • The Lady Davis Carmel Medical Center, 7 Michal st.

    Haifa, 3436212, Israel

  • The Methodist Hospital Research Institute

    Houston, Texas, 77030, United States

  • The Newcastle upon Tyne Hospitals NHS Foundation Trust, Sir William Leech Lung Research Centre

    Newcastle upon Tyne, Tyne and Wear, NE7 7DN, United Kingdom

  • The Ohio State University Wexner Medical Center

    Columbus, Ohio, 43210, United States

  • The Prince Charles Hospital

    Chermside, Queensland, 4032, Australia

  • Thomas Jefferson University Hospital

    Philadelphia, Pennsylvania, 19107, United States

  • Thoraxklinik-Heidelberg Zentrum für Pulmonale Hypertonie

    Heidelberg, Baden-Wurttemberg, 69126, Germany

  • Tufts Medical Center

    Boston, Massachusetts, 02111, United States

  • UCSD Health Sciences

    La Jolla, California, 92037, United States

  • UNESP-Faculdade de Medicina da Universidade Estadual Paulista Campus Botucatu

    Botucatu, São Paulo, 18618-687, Brazil

  • UT Southwestern Medical Center

    Dallas, Texas, 75390, United States

  • UZ Leuven, UZ Leuven Campus Gasthuisberg, Herestraat 49

    Leuven, 3000, Belgium

  • Uludag Universitesi Tip Fakültesi, Gorukle Kampusu

    Bursa, 16059, Turkey (Türkiye)

  • Unidad de Investigacion Clinica en Medicina, S.C.

    Monterrey, N.L., 64718, Mexico

  • Universitaetsklinikum Carl Gustav Carus TU Dresden

    Dresden, 01307, Germany

  • Universitaetsklinikum Hamburg-Eppendorf

    Hamburg, 20246, Germany

  • Universitaetsklinikum des Saarlandes, Innere Medizin V, IMED, Kirrberger Strasse 100, Gebäude 41

    Homburg, Saarland, 66424, Germany

  • Universitaetsmedizin der Johannes-Gutenberg-Universitaet Mainz, Zentrum für Kardiologie I, Centrum für Thrombose und Hämostase (CTH), Langenbeckstrasse 1

    Mainz, Rhineland-Palatinate, 55131, Germany

  • University Clinic for Pulmonary Diseases, Jordanovac 104

    Zagreb, 10000, Croatia

  • University General Hospital Attikon

    Chaïdári, 12462, Greece

  • University General Hospital of Alexandroupolis

    Alexandroupoli, 68100, Greece

  • University Health Network-Toronto General Hospital

    Toronto, Ontario, M5G 2N2, Canada

  • University of Alabama at Birmingham

    Birmingham, Alabama, 35294, United States

  • University of Arizona

    Tucson, Arizona, 85724, United States

  • University of California Davis Medical Center

    Sacramento, California, 95817, United States

  • University of California, Irvine

    Orange, California, 19103, United States

  • University of Chicago Medical Center

    Chicago, Illinois, 60637, United States

  • University of Cincinnati-Medical Science Building

    Cincinnati, Ohio, 45267, United States

  • University of Colorado Hospital

    Aurora, Colorado, 80045, United States

  • University of Florida

    Gainesville, Florida, 32610, United States

  • University of Iowa Hospitals and Clinics

    Iowa City, Iowa, 52242, United States

  • University of Maryland Medical Center

    Baltimore, Maryland, 21201, United States

  • University of Miami

    Miami, Florida, 33136, United States

  • University of New Mexico

    Albuquerque, New Mexico, 87131, United States

  • University of Pennsylvania

    Philadelphia, Pennsylvania, 19104, United States

  • University of Rochester

    Rochester, New York, 14642, United States

  • University of Virginia Medical Center

    Charlottesville, Virginia, 22908, United States

  • Universitätsklinikum Leipzig, Medizinische Klinik II, Pneumologie

    Leipzig, Saxony, 04103, Germany

  • Universitätsmedizin Greifswald

    Greifswald, Mecklenburg-Vorpommern, 17475, Germany

  • Uniwersytecki Szpital Kliniczny w Bialymstoku, Klinika Kardiologii z Oddzialem Intensywnego Nazdoru Kardiologicznego, M. Sklodowskiej 24a

    Bialystok, 15-276, Poland

  • VA Greater Los Angeles Healthcare System

    Los Angeles, California, 90073, United States

  • VU Medisch Centrum, De Boelelaan 1117

    Amsterdam, 1081 HV, Netherlands

  • Vermont Lung Center

    Colchester, Vermont, 05446, United States

  • Vseobecna fakultni nemocnice v Praze, II. interni klinika kardiologie a angiologie VFN a 1. LF UK, U nemocnice 2

    Prague, 128 08, Czechia

  • Washington University School of Medicine

    St Louis, Missouri, 63110, United States

  • Weill-Cornell-New York Presbyterian Hospital

    New York, New York, 10021, United States

  • Westmead Hospital

    Sydney, New South Wales, 2145, Australia

  • Winthrop Hospital

    Mineola, New York, 11501, United States

  • Xiangya Hospital Central South University

    Changsha, Hunan, 410008, China

  • Århus Universitetshospital

    Aarhus, 8200, Denmark

Conditions

Explore the condition pages connected to this study.