New hope for kidney disease: first human trial of PYC-003 begins

NCT ID NCT06714006

Recruiting now Disease control Sponsor: PYC Therapeutics Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jul 28, 2026 · Updated 2 times

Summary

This study is the first time a new drug called PYC-003 is being tested in humans. It is for people with a genetic kidney disease that causes cysts to grow and damage the kidneys. The trial will first test the drug in healthy volunteers to check safety, then in patients with the disease. The main goal is to see if the drug is safe and how the body processes it.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PYC-003 (a peptide attached to a synthetic DNA-like molecule)
What this could lead to: If this early trial shows the drug is safe, it could pave the way for a treatment that slows or stops kidney cysts from growing in people with ADPKD.
What could go wrong: This is a very early Phase 1 study, so the main goal is just to check safety. It is too soon to know if the drug will actually help the disease, and side effects are possible.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

autosomal dominant polycystic kidney disease polycystic kidney disease 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

AUTOSOMAL DOMINANT POLYCYSTIC KIDNEY DISEASE (ADPKD)

Contacts and locations

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Locations

Concord Repatriation General Hospital
RECRUITING

Concord, New South Wales, 2139, Australia
Linear Clinical Research
RECRUITING

Joondalup, Western Australia, 6027, Australia
Liverpool Hospital, Clinic G-Reception 133, Level 1, Clinical Building, Burnside Drive
RECRUITING

Liverpool, New South Wales, 2170, Australia
Mater Hospital Brisbane
RECRUITING

South Brisbane, Queensland, 4101, Australia
Pacific Clinical Research Network Auckland
RECRUITING

Takapuna, Auckland, 0622, New Zealand
Prince of Wales Hospital
RECRUITING

Shatin, New Territories, Hong Kong
Scientia Clinical Research
RECRUITING

Randwick, New South Wales, 2031, Australia

Contact Email: •••••@•••••
South Coast Renal, Brockway House, Level 1, Suite 8, 82-86 Queen Street,
RECRUITING

Southport, Gold Coast, 4125, Australia
St Vincent's Hospital Melbourne
RECRUITING

Fitzroy, Victoria, 3056, Australia
Sunshine Hospital, Western Centre for Health Research and Education, Level 3, 176-190 Furlong Road
RECRUITING

Saint Albans, Victoria, 3021, Australia
Sydney Adventist Hospital
RECRUITING

Wahroonga, New South Wales, 2076, Australia
Westmead Hospital, Clinical Research Unit, Level 6, B Wing/Building, Hawkesbury Road
RECRUITING

Westmead, New South Wales, 2145, Australia

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