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Magic mushroom compound tested for phantom limb pain

NCT ID NCT05224336

Completed Symptom relief Sponsor: University of California, San Diego Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This small pilot study tested whether psilocybin, the active ingredient in magic mushrooms, can be safely given to people with chronic phantom limb pain after an amputation. Ten participants received either psilocybin or a placebo (niacin) in a supportive setting. The main goals were to check safety and see if pain scores improved. Early results suggest it may be safe and could reduce pain, but larger studies are needed.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance
psilocybin
What this could lead to
If it works, this could point toward a new treatment option for phantom limb pain that reduces pain intensity.
What could go wrong
This is a very early Phase 1 trial with only 10 participants, so results may not apply to everyone. Psilocybin can cause temporary psychological distress.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Chronic Pain Pain Phantom Limb

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

PHANTOM LIMB PAIN

Contacts and locations

Locations

  • University of California, San Diego

    San Diego, California, 92093, United States

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