Magic mushroom compound shows promise for depression in new trial
NCT ID NCT06746441
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This completed phase 2 trial tested whether psilocybin (the active ingredient in magic mushrooms) alone or combined with cognitive behavioral therapy (CBT) can help people with major depression. Sixty adults aged 18-70 with active depression took part. Researchers measured changes in depression scores, anxiety, and biological markers like brain chemicals and inflammation. The goal is to see if psilocybin can offer a new treatment option for depression.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
psilocybin (a psychedelic compound from magic mushrooms)
What this could lead to
If it works, this could point toward a new way to treat depression using psilocybin, possibly with fewer side effects than standard antidepressants.
What could go wrong
This is a small, early-phase trial with only 60 people, so results may not apply to everyone. Psilocybin can cause intense psychological effects and is not yet approved for depression.
Disclaimer
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the original study
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Lady Reading Hospital, Pakistan
Peshawar, Khyber Pakhtunkhwa, 25000, Pakistan