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Brain surgery for Parkinson's: can we foresee the confusion that follows?

NCT ID NCT07792265

Knowledge-focused Sponsor: Beijing Tiantan Hospital Source: ClinicalTrials.gov ↗

What the study statuses mean

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Aug 28, 2026 · Last updated Aug 28, 2026

Summary

This study follows 400 Parkinson's disease patients who are scheduled for deep brain stimulation (DBS) surgery, a treatment that uses implanted electrodes to ease motor symptoms. After the operation, some patients experience postoperative delirium, a state of confusion that can slow recovery and affect long-term brain function. Researchers will track how often delirium occurs in the first three days after surgery and examine whether anesthesia choices, patient health, and other factors can predict it. The goal is to build a model that helps doctors anticipate and prevent this complication.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Deep brain stimulation (DBS) surgery and anesthesia management
What this could lead to
If successful, this could lead to a prediction model that helps doctors identify Parkinson's patients at high risk of delirium after DBS surgery, potentially reducing complications and improving recovery.
What could go wrong
This is an observational study, so it cannot prove cause and effect. The prediction model may not be accurate enough for routine use, and findings may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

400 people

The number who actually took part.

Started

May 2022

Finished

Jan 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

This study will enroll patients diagnosed with Parkinson's Disease (PD) who are scheduled to undergo bilateral Subthalamic Nucleus Deep Brain Stimulation (STN-DBS) surgery at Beijing Tiantan Hospital. The target population consists of adult patients aged 50 to 80 years with idiopathic Parkinson's Disease who are indicated for DBS surgery due to motor complications despite optimal medical therapy. Participants will be recruited consecutively from the outpatient department of Neurology and Functional Neurosurgery at Beijing Tiantan Hospital. A total sample size of 400 patients is planned to ensure adequate statistical power for the analysis of postoperative delirium incidence and risk factors.

Ages

50 to 80 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Aged 50-80 years old * American Society of Anesthesiologists (ASA) physical status classification II-III * Scheduled for bilateral subthalamic nucleus deep brain stimulation (STN-DBS) for Parkinson's disease * Signed informed consent prior to enrollment Exclusion Criteria: * Obstructive sleep apnea * Body mass index (BMI) \>30 kg/m² * Predicted difficult airway * Severe preoperative anxiety * Severe dysfunction of vital organs (e.g., heart failure, renal or hepatic dysfunction) * History of allergy to anesthetic agents

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Conditions

The condition(s) this trial relates to.

Emergence Delirium Parkinson disease

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Deep brain stimulation Parkinson disease (disorder) Postoperative delirium

Contacts and locations

Locations

  • Beijing Tian Tan Hospital

    Beijing, 100070, China

More trials for these conditions

Other studies related to the condition(s) this trial covers.