New model may help decide which preterm babies need platelet transfusions

NCT ID NCT06043050

Completed Knowledge-focused Sponsor: Leiden University Medical Center Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jun 26, 2026 · Updated 2 times

Summary

This study looked at data from over 1000 preterm babies with low platelet counts to build a model that predicts their risk of major bleeding or death. The goal is to help doctors decide when a platelet transfusion is truly needed, since current guidelines based only on platelet count may not be enough. The model considers each baby's changing condition over time to give personalized risk estimates.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: Platelet transfusion
What this could lead to: If successful, this model could help doctors decide which preterm babies truly need platelet transfusions, reducing unnecessary treatments and complications.
What could go wrong: This is an observational study, not a trial, so it can't prove cause and effect. The model needs further testing before it can be used in practice.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Hemorrhage neonatal thrombocytopenia thrombocytopenia

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

INTRAVENTRICULAR HEMORRHAGE NEONATAL THROMBOCYTOPENIA PLATELET TRANSFUSION

Contacts and locations

Locations

Amsterdam University Medical Center, Emma Children's hospital, location AMC

Amsterdam, North Holland, 1105 AZ, Netherlands
Amsterdam University Medical Center, Emma Children's hospital, location VUmc

Amsterdam, North Holland, 1081 HV, Netherlands
Charité - Universitätsmedizin Berlin

Berlin, Metropolregion Berlin-Brandenburg, 10117, Germany
Erasmus University Medical Center, Sophia pediatric hospital

Rotterdam, South Holland, 3015 CN, Netherlands
Isala clinics

Zwolle, Overijssel, 8025 AB, Netherlands
Karolinska University Hospital

Stockholm, Södermanland and Uppland, 171 76, Sweden
Leiden University Medical Center, Willem Alexander Children's hospital

Leiden, South Holland, 2333 ZA, Netherlands
Maastricht University Medical Center, MosaKids

Maastricht, Limburg, 6229 HX, Netherlands
Máxima Medical Center

Veldhoven, North Brabant, 5504 DB, Netherlands
Radboud University Medical Center, Amalia Children's hospital

Nijmegen, Gelderland, 6525 GA, Netherlands
University Medical Center Groningen, Beatrix Children's hospital

Groningen, Provincie Groningen, 9713 GZ, Netherlands
University Medical Center Utrecht, Wilhelmina Children's hospital

Utrecht, Utrecht, 3584 EA, Netherlands

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