Blood-Based injection may ease Post-Spinal headaches

NCT ID NCT06790758

Completed Symptom relief Sponsor: Tanta University Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study tested whether an injection of plasma-rich fibrin (a substance made from the patient's own blood) could relieve severe headaches that sometimes occur after a spinal tap or epidural. Sixty adults with this type of headache received the injection through a special catheter. Researchers measured pain levels and how long patients needed bed rest, aiming to see if the treatment provides relief.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: plasma-rich fibrin
What this could lead to: If it works, this could offer a new treatment option for severe headaches caused by spinal fluid leaks.
What could go wrong: This is a small, completed study without a control group, so results may not be definitive. The procedure carries risks like infection or allergic reaction.

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Conditions

The condition(s) this trial relates to.

intracranial hypotension Post-Dural Puncture Headache

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

EPIDURAL OPTIC NERVE SHEATH DIAMETER PLASMA RICH FIBRIN POSTDURAL PUNCTURE HEADACHE RACZ CATHETER

Contacts and locations

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Locations

Tanta University

Tanta, El-Gharbia, 31527, Egypt

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