New hope for muscle stiffness: experimental drug PGN-EDODM1 enters Mid-Stage trial

NCT ID NCT06667453

Recruiting now Disease control Sponsor: PepGen Inc Source: ClinicalTrials.gov ↗

First seen Jun 24, 2026 · Last updated Jul 30, 2026 · Updated 3 times

Summary

This study tests an investigational drug called PGN-EDODM1 in 24 adults with myotonic dystrophy type 1, a condition causing muscle stiffness and weakness. Participants receive multiple doses of the drug or a placebo by IV to check safety and how the body processes it. The goal is to see if the drug is safe and tolerable.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PGN-EDODM1
What this could lead to: If successful, this could point toward a treatment that controls symptoms of myotonic dystrophy type 1, like muscle stiffness and weakness.
What could go wrong: This is an early Phase 2 trial with only 24 participants, so results may not apply to everyone. The drug is still experimental and may not work or could have side effects.

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Conditions

The condition(s) this trial relates to.

myotonic dystrophy myotonic dystrophy type 1

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MYOTONIC DYSTROPHY 1

Contacts and locations

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Study contacts

Contact

Email: •••••@•••••

Locations

CIUSSS du Saguenay-Lac-Saint-Jean
RECRUITING

Chicoutimi, Quebec, Canada
Cardiff and Vale Hospital
RECRUITING

Cardiff, United Kingdom

Contact Email: •••••@•••••
Kyungpook National University Chilgok Hospital
RECRUITING

Daegu, South Korea
Montreal Neurological Institute
RECRUITING

Montreal, Quebec, H3A 2B4, Canada

Contact Email: •••••@•••••
Newcastle Upon Tyne Hospitals
RECRUITING

Newcastle upon Tyne, NE7 7DN, United Kingdom

Contact Email: •••••@•••••
Ottawa Hospital Research Institute (OHRI)
RECRUITING

Ottawa, Ontario, Canada
Pacific Clinical Research Network Auckland
RECRUITING

Takapuna, Auckland, 0622, New Zealand
Pusan National University Yangsan Hospital
RECRUITING

Pusan, Gyeongsangnam-do, South Korea

Contact Email: •••••@•••••
Salford Royal Hospital
RECRUITING

Salford, England, United Kingdom

Contact Email: •••••@•••••
Seoul National University Hospital
RECRUITING

Seoul, South Korea
University College London Hospitals NHS Foundation Trust
RECRUITING

London, UK, United Kingdom

Contact Email: •••••@•••••
University of Calgary
RECRUITING

Calgary, Alberta, T2N 4Z6, Canada

Contact Email: •••••@•••••

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