New Opioid-Like drug aims to ease Post-Surgery pain

NCT ID NCT06602271

Recruiting now Symptom relief Sponsor: Ensysce Biosciences Source: ClinicalTrials.gov ↗

First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new drug called PF614, a modified form of oxycodone, for people with moderate to severe pain after tummy tuck surgery. About 320 adults will take either the drug or a placebo every 12 hours for up to 4 days. Researchers will measure pain relief and watch for side effects.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: PF614 (an oxycodone prodrug extended-release capsule)
What this could lead to: If it works, this could provide a new option for managing pain after surgery with potentially less risk of misuse.
What could go wrong: This is a Phase 3 trial, but it's still testing against placebo, and results may not apply to other types of pain. As an opioid, PF614 carries risks of side effects and dependence.

This is an AI summary of the original study and may miss details. Read our disclaimer.

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Conditions

The condition(s) this trial relates to.

Pain, Postoperative

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

POSTOPERATIVE PAIN, ACUTE

Contacts and locations

Locations

CenExel / Atlanta Center for Medical Research (ACMR)
RECRUITING

Atlanta, Georgia, 30331, United States
CenExel / JBR
RECRUITING

Salt Lake City, Utah, 84107, United States
HD Research - Memorial Hermann Surgery Center
RECRUITING

Houston, Texas, 77043, United States

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