Scientists probe immune system clues in panic disorder

NCT ID NCT07444879

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First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study looks at whether certain immune system markers (IL-33, sST2, and CRP) are different in people with panic disorder compared to healthy individuals. Researchers will measure these markers in blood samples from 80 participants who have never taken medication for panic disorder. The goal is to better understand the role of inflammation in panic disorder, not to test a treatment.

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Study facts

What this study's own registry entry says, in plain language.

Participants

About 80 people

The number the study aims to enrol. It can still change while the study runs.

Started

Jul 2025

Expected to finish

Mar 2026

An estimate. End dates often move.

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of adult participants aged 18-65 years. The panic disorder (PD) group included consecutive subjects diagnosed with PD according to DSM-5-TR criteria who were admitted to the psychiatry clinic of Elazığ Mental Health and Diseases Hospital (Turkey). The healthy control (HC) group consisted of individuals from the general population who applied to the hospital medical board and had no current or past psychiatric or significant medical disorders. All participants provided informed consent prior to enrollment.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. For Panic Disorder (PD) Group: \*Inclusion Criteria: * Being between 18-65 years of age * Having a diagnosis of panic disorder (PD) according to DSM-5-TR and having presented to the hospital with panic attack symptoms of the disorder * Not having previously used any medication for psychiatric purposes (drug-naive) * Not having any additional active psychiatric disorders besides PD at the current presentation * Absence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer * Not having taken any medication or supplements in the last month * Completing sociodemographic and scale data fully * Volunteering to participate in the study For PD Group: \*Exclusion Criteria: • Being outside the 18-65 age range • Not meeting the diagnostic criteria for PD according to DSM-5-TR or being in good health • Having a history of psychiatric medication use • Having an additional psychiatric disorder besides PD at the current application • Presence of hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, cancer • Patients with a body mass index (BMI) \<18.5 kg/m² and \>29.9 kg/m² * Taking any medication or supplement in the last month * Incomplete completion of sociodemographic and scale data * Not volunteering to participate in the study 2. For Healthy Control Group: * Inclusion Criteria: * Being between 18-65 years of age * Not having any active psychiatric disorder * Not having previously used any medication for psychiatric purposes (drug-naive) * Not having hypertension, diabetes mellitus, kidney failure, liver failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer * Not having taken any medication or supplement in the last month * Completing sociodemographic and scale data fully * Volunteering to participate in the study For Healthy Control Group: \*Exclusion Criteria: * Being outside the 18-65 age range * Having any active psychiatric disorder * Having a history of using psychiatric medication * Having hypertension, diabetes mellitus, renal failure, hepatic failure, neurological disease with cognitive impairment, acute infection, pregnancy, autoimmune disease, or cancer * Patients with a body mass index (BMI) \< 18.5 kg/m² and \> 29.9 kg/m² * Taking any medication or supplement in the last month * Incomplete completion of sociodemographic and scale data * Not volunteering to participate in the study

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Conditions

The condition(s) this trial relates to.

As listed by the trial registrant

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How to take part

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Contacts and locations

Locations

  • Elazığ Mental Health and Diseases Hospital Psychiatry Clinic

    RECRUITING

    Elâzığ, Elâzığ, 23200, Turkey (Türkiye)

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