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Scientists investigate enzyme link to panic disorder

NCT ID NCT07424911

Knowledge-focused Sponsor: Elazığ Mental Health and Diseases Hospital Source: ClinicalTrials.gov ↗

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Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jun 24, 2026 · Last updated Jun 30, 2026 · Updated 3 times

Summary

This study looked at levels of a specific enzyme, α-N-acetylgalactosaminidase, in the blood of people with panic disorder who had never taken medication. Researchers compared these levels to healthy individuals and checked for connections with symptom severity and inflammation. The goal was to better understand the biology behind panic disorder.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

What this could lead to
If successful, this could point toward a biological marker for panic disorder, potentially aiding future diagnosis or treatment.
What could go wrong
This is a small, early observational study, not a treatment trial. The enzyme may not prove to be a reliable marker, and results may not apply to all patients.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Participants

66 people

The number who actually took part.

Started

May 2025

Finished

Aug 2025

Lead sponsor

A government agency

The lead sponsor is a government body.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Who is studied

The study population consisted of adult outpatients aged 18-65 years. The Panic Disorder (PD) group included consecutive, drug-naïve patients diagnosed with PD according to DSM-5-TR criteria who were admitted to the psychiatry outpatient clinic of Elazığ Mental Health and Diseases Hospital (Turkey). The healthy control (HC) group consisted of individuals from the general population who applied to the hospital medical board and had no current or past psychiatric or significant medical disorders. All participants provided informed consent prior to enrollment.

Ages

18 to 65 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

1. For Panic Disorder (PD) Group: * Inclusion Criteria: * Age ≥18 years and \<65 years * Diagnosis of PD according to DSM-5-TR * Drug-naïve at baseline * Exclusion Criteria: * Age \<18 years and \>65 years * Any psychiatric diagnosis other than PD * Active alcohol or substance use disorder * Significant medical illness * Incomplete follow-up 2. For Healthy Control (HC) Group: * Inclusion Criteria: • Age ≥18 years and \<65 years * Exclusion Criteria: * Age \<18 years and \>65 years * Any psychiatric diagnosis * Active alcohol or substance use disorder * Significant medical illness

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Conditions

The condition(s) this trial relates to.

panic disorder

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Panic disorder

Contacts and locations

Locations

  • Mehmet Hamdi ÖRÜM

    Elâzığ, Elâzığ, 23200, Turkey (Türkiye)

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