New pill targets common cancer mutation in early trial
NCT ID NCT06585488
First seen Jun 26, 2026 · Last updated Jul 09, 2026 · Updated 3 times
Summary
This early-phase study tested a new drug called BGB-53038, which blocks a family of KRAS proteins that help some cancers grow. It was given alone or with other drugs to 47 people with advanced solid tumors (like lung, colon, or pancreatic cancer) that have KRAS mutations. The main goals were to check safety and find the right dose, but the study was stopped early, so results are limited.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- BGB-53038 (a Pan-KRAS inhibitor pill), sometimes combined with tislelizumab or cetuximab infusions
- What this could lead to
- If it works, this could point toward a new treatment option for several hard-to-treat cancers with KRAS mutations.
- What could go wrong
- This is a very early (phase 1) trial that was terminated, so results are limited. The drug may not prove effective or safe in larger studies.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Asan Medical Center
SongpaGu, Seoul Teugbyeolsi, 05505, South Korea
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Auckland City Hospital
Auckland, 1023, New Zealand
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Beijing Cancer Hospital
Beijing, Beijing Municipality, 100142, China
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Blacktown Cancer and Haematology Centre
Blacktown, New South Wales, NSW 2148, Australia
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Cancer Hospital Chinese Academy of Medical Sciences
Beijing, Beijing Municipality, 100021, China
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Linear Clinical Research
Nedlands, Western Australia, WA 6009, Australia
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Monash Health
Clayton, Victoria, VIC 3168, Australia
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Peter Maccallum Cancer Centre
Melbourne, Victoria, VIC 3000, Australia
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Samsung Medical Center
GangnamGu, Seoul Teugbyeolsi, 06351, South Korea
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Seoul National University Bundang Hospital
Seongnam-si, Gyeonggi-do, 13620, South Korea
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Seoul National University Hospital
Seoul, Seoul Teugbyeolsi, 03080, South Korea
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Severance Hospital Yonsei University Health System
SeodaemunGu, Seoul Teugbyeolsi, 03722, South Korea
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Shanxi Provincial Cancer Hospital
Taiyuan, Shanxi, 030013, China
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Sidney Kimmel Comprehensive Cancer At Johns Hopkins
Baltimore, Maryland, 21287, United States
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The University of Texas Md Anderson Cancer Center
Houston, Texas, 77030-4009, United States
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University of Kansas Medical Center Research Institute
Kansas City, Kansas, 66160-8500, United States
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Usc Norris Comprehensive Cancer Center (Nccc)
Los Angeles, California, 90089-1019, United States
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