New hope for polycythemia vera patients who Can't use standard drugs
NCT ID NCT04182100
First seen Jun 26, 2026 · Last updated Jun 26, 2026
Summary
This Phase 2 study tested a drug called P1101 (ropeginterferon alfa-2b) in 29 Japanese adults with polycythemia vera (PV), a blood disorder that causes too many red blood cells. The participants were people for whom standard treatments are hard to use, such as younger patients or those with certain symptoms. The goal was to see if P1101 could control blood counts without needing phlebotomy (blood removal). The drug was injected under the skin every two weeks, with doses adjusted over time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
Active substance
P1101 (ropeginterferon alfa-2b)
What this could lead to
If successful, P1101 could offer a new treatment option for polycythemia vera patients who cannot tolerate or do not respond to current standard therapies.
What could go wrong
This is a small, single-arm Phase 2 trial with only 29 patients, so results may not apply broadly. The drug may cause side effects like flu-like symptoms, and long-term safety is not yet established.
Disclaimer
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This is a summary of
the original study
.
Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
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Locations
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Ehime University Hospital
Toon-shi, Ehime, 791-0295, Japan
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Juntendo University Hospital
Bunkyo-ku, Tokyo, 113-8431, Japan
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Keio University Hospital
Shinjuku-ku, Tokyo, 160-8582, Japan
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Mie University Hospital
Tsu, Mie-ken, Japan
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NTT Medical Center Tokyo
Shinagawa-ku, Tokyo, 141-8625, Japan
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Osaka University Hospital
Suita-shi, Osaka, 565-0871, Japan
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Tokyo Medical University Hospital
Shinjuku-ku, Tokyo, 160-0023, Japan
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University of Yamanashi Hospital
Chuo-shi, Yamanashi, 409-3898, Japan