New daily pill aims to help millions shed pounds and improve health

NCT ID NCT05869903

Ongoing Disease control Sponsor: Eli Lilly and Company Source: ClinicalTrials.gov ↗

Summary

This large, late-stage study is testing whether a once-daily oral medication called orforglipron can help adults with obesity or overweight lose weight and improve related health conditions like high blood pressure or cholesterol. Over 3,100 participants will take the drug or a placebo for 72 weeks to see how much weight they lose and if it helps their overall health. The study also includes a longer extension phase to see if the treatment can delay the onset of type 2 diabetes in some participants.

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

AMCR Institute

Escondido, California, 92025, United States
Adachi Kyosai Hospital

Adachi-ku, Tokyo, 120-0022, Japan
Affiliated Hospital of Jiangsu University

Zhenjiang, Jiangsu, 212000, China
Ajou University Hospital

Suwon, Kyǒnggi-do, 16499, South Korea
All India Institute of Medical Sciences (AIIMS) - Nagpur

Nagpur, Maharashtra, 441108, India
Alliance for Multispecialty Research, LLC

Norman, Oklahoma, 73069, United States
Arcturus Healthcare , PLC, Troy Internal Medicine Research Division

Troy, Michigan, 48098, United States
Areteus s.r.o.

Trebišov, Košice Region, 075 01, Slovakia
Boocs Clinic Fukuoka

Fukuoka, 812-0025, Japan
CECIP - Centro de Estudos do Interior Paulista

Jaú, São Paulo, 17201130, Brazil
CEDOES

Vitória, Espírito Santo, 29055450, Brazil
CEPIC - Centro Paulista de Investigação Clínica

São Paulo, 04266-010, Brazil
CHUAC-Complejo Hospitalario Universitario A Coruña

A Coruña, A Coruña [La Coruña], 15006, Spain
CPQuali Pesquisa Clínica

São Paulo, 01228-000, Brazil
Care Access - Lake Charles

Lake Charles, Louisiana, 70601, United States
Catalina Research Institute, LLC

Montclair, California, 91763, United States
Cedar Health Research

Dallas, Texas, 75251, United States
Central India Cardiology and Research Institute

Nagpur, Maharashtra, 440015, India
Centro Multidisciplinar de Estudos Clinicos

São Bernardo do Campo, São Paulo, 09715-090, Brazil
Centro Médico Teknon

Barcelona, Barcelona [Barcelona], 08022, Spain
Centro Periférico de Especialidades Bola Azul

Almería, Almería, 04009, Spain
Centro de Pesquisa Sao Lucas

Campinas, São Paulo, 13060-803, Brazil
Centro de Pesquisas em Diabetes e Doenças Endócrino-Metabólicas

Fortaleza, Ceará, 60430-350, Brazil
Chang Gung Memorial Hospital at Kaohsiung

Kaohsiung Niao Sung Dist, Kaohsiung, 83301, Taiwan
Changhua Christian Hospital

Changhua, 50006, Taiwan
Chiayi Christian Hospital

Chiayi City, Chiayi, 600, Taiwan
Chinese PLA General Hospital

Beijing, Beijing Municipality, 100853, China
Chongqing General Hospital

Chongqing, Chongqing Municipality, 404117, China
Cline Research Center

Curitiba, Paraná, 80030-480, Brazil
Clinical Research Institute of Arizona (CRI) - Sun City West

Sun City West, Arizona, 85375, United States
Clinical Site Partners, LLC dba Flourish Research

Winter Park, Florida, 32789, United States
Complejo Hospitalario Universitario de Ferrol (CHUF)- Hospital Naval

Ferrol, A Coruña [La Coruña], 15405, Spain
Consano Clinical Research, LLC

Shavano Park, Texas, 78231, United States
Cotton O'Neil Clinical Research Center

Topeka, Kansas, 66606, United States
Cotton O'Neil Diabetes & Endocrinology

Topeka, Kansas, 66606, United States
DIA-MED CENTRUM s.r.o.

Púchov, Trenčín Region, 020 01, Slovakia
DIAB sro

Rožňava, Košický Kr, 048 01, Slovakia
Deenanath Mangeshkar Hospital & Research Centre

Pune, Maharashtra, 411004, India
Dorado Medical Complex

Dorado, 00646, Puerto Rico
East Coast Institute for Research, LLC

Macon, Georgia, 31210, United States
East-West Medical Research Institute

Honolulu, Hawaii, 96814, United States
Eastside Research Associates

Redmond, Washington, 98052, United States
Elite Clinical Trials

Blackfoot, Idaho, 83221, United States
Endocrine and Metabolic Consultants

Rockville, Maryland, 20852, United States
Endolife Speciality Hospitals

Guntur, Andhra Pradesh, 522001, India
Fukuwa Clinic

Chuo-ku, Tokyo, 104-0031, Japan
GCM Medical Group, PSC - Hato Rey Site

San Juan, PR, 00917, Puerto Rico
Gachon University Gil Medical Center

Namdong-gu, Incheon-gw, 21565, South Korea
Hainan General Hospital

Haikou, Hainan, 570311, China
Hallym University Sacred Heart Hospital

Anyang-si, Kyǒnggi-do, 14068, South Korea
Health Research of Hampton Roads, Inc.

Newport News, Virginia, 23606, United States
Heishinkai Medical Group ToCROM Clinic

Shinjuku-ku, Tokyo, 160-0008, Japan
Hospital Clínico Universitario de Valladolid

Valladolid, Castille and León, 47010, Spain
Hospital General Universitario de Valencia

Valencia, Valenciana, Comunitat, 46014, Spain
Hospital Germans Trias i Pujol

Badalona, Barcelona [Barcelona], 08916, Spain
Hospital Quiron Infanta Luisa

Seville, Andalusia, 41010, Spain
Hospital São Domingos

Bequimão, Maranhão, 65060-645, Brazil
Hospital São Lucas de Copacabana

Rio de Janeiro, 22061-080, Brazil
Hospital Universitari Vall d'Hebron

Barcelona, Barcelona [Barcelona], 08035, Spain
Hospital Universitari i Politecnic La Fe

Valencia, 46026, Spain
Hospital Universitario Virgen de la Victoria

Málaga, Andalusia, 29010, Spain
Hospital Virgen de las Montañas

Villamartín, Cádiz, 11650, Spain
Hospital Virgen del Camino

Sanlúcar de Barrameda, Cádiz, 11540, Spain
Hospital das Clinicas FMUSP

São Paulo, 05403-000, Brazil
Human Care s.r.o.

Košice, Košice Region, 04001, Slovakia
Integral Pesquisa e Ensino

Votuporanga, São Paulo, 15501-405, Brazil
Iwamoto Internal Medicine Clinic

Zentsujichó, Kagawa-ken, 765-0071, Japan
Jedidiah Clinical Research - Tampa - Bay Plaza

Tampa, Florida, 33619, United States
Jiading District Central Hospital

Shanghai, Shanghai Municipality, 201800, China
Jiangxi Provincial People's Hospital

Nanchang, Jiangxi, 330006, China
Jinan Central Hospital

Jinan, Shandong, 250013, China
John Muir Physician Network Research Center

Concord, California, 94520, United States
Juno Research

Houston, Texas, 77054, United States
Kanno Naika

Mitaka, Tokyo, 181-0013, Japan
Kaohsiung Medical University Chung-Ho Memorial Hospital

Kaohsiung City, 807, Taiwan
Konyang University Hospital

Seogu, Taejǒn-Kwangyǒkshi, 35365, South Korea
Korea University Ansan Hospital

Ansan-si, Kyǒnggi-do, 15355, South Korea
Las Vegas Medical Research

Las Vegas, Nevada, 89128, United States
Lifepoint Multispeciality Hospital

Pune, Maharashtra, 411057, India
Long Island Cardiovascular Consultants

Lake Success, New York, 11042, United States
MEDI-DIA s.r.o.

Sabinov, Presov, 083 01, Slovakia
Mazda Hospital

Aki-gun, Hiroshima, 735-0017, Japan
MedStar Health Research Institute (MedStar Physician Based Research Network)

Hyattsville, Maryland, 20782, United States
MediTask

Bratislava, 831 03, Slovakia
Medical Corporation Chiseikai Tokyo Center Clinic

Chuo-ku, Tokyo, 103-0027, Japan
Medical Corporation Heishinkai OCROM Clinic

Suita-shi, Osaka, 565-0853, Japan
Metabol KLINIK

Bratislava, Bratislava Region, 811 08, Slovakia
Mysore Medical College

Mysore, Karnataka, 570001, India
NTT Nishinihon Takamatsu Clinic

Takamatsu, Kagawa-ken, 760-0076, Japan
Nanjing First Hospital

Nanjing, Jiangsu, 210006, China
National Cheng Kung University Hospital

Tainan, 704, Taiwan
Nemocnica s poliklinikou Lucenec

Lučenec, Banská Bystrica Region, 984 01, Slovakia
New Age Medical Research Corporation

Miami, Florida, 33186, United States
Ningbo First Hospital

Ningbo, Zhejiang, 315010, China
NorCal Medical Research, Inc

Greenbrae, California, 94904, United States
Norcal Endocrinology & Internal Medicine

San Ramon, California, 94583, United States
Núcleo de Pesquisa Clínica do Rio Grande do Sul

Porto Alegre, Rio Grande do Sul, 90430-001, Brazil
Oishi Clinic

Wakasugi, Fukuoka, 811-2310, Japan
Osaka Nishiumeda Clinic

Osaka, 530-0001, Japan
Pennington Biomedical Research Center

Baton Rouge, Louisiana, 70808, United States
Physicians Research Associates

Lawrenceville, Georgia, 30046, United States
Physicians' Research Options

Draper, Utah, 84020, United States
Pusan National University Yangsan Hospital

Busan, Kyǒngsangnam-do, 50612, South Korea
Quanta Diagnóstico e Terapia

Curitiba, Paraná, 80045170, Brazil
Renstar Medical Research

Ocala, Florida, 34470, United States
Rophe Adult and Pediatric Medicine/SKYCRNG

Union City, Georgia, 30291, United States
SKY Integrative Medical Center/SKYCRNG

Ridgeland, Mississippi, 39157, United States
Sahyadri Super Speciality Hospital

Pune, Maharashtra, 411004, India
Seoul National University Hospital

Seoul, Seoul-teukbyeolsi [Seoul], 03080, South Korea
ShenZhen People's Hospital

Shenzhen, Guangdong, 518020, China
Shimokitazawa Tomo Clinic

Setagaya-ku, Tokyo, 155-0031, Japan
Soma Clinical Trials

Wylie, Texas, 75098, United States
South Broward Research

Miramar, Florida, 33027, United States
Sugiura Internal Medicine Clinic

Sōka, Saitama, 340-0015, Japan
Texas Diabetes & Endocrinology, P.A.

Austin, Texas, 78731, United States
The First Affiliated Hospital of Henan University of Science &Technology

Luoyang Shi, Henan, 471003, China
The First Affiliated Hospital of Soochow University

Suzhou, Jiangsu, 215006, China
The First People's Hospital of Yunnan Province

Kunming, Yunnan, 650034, China
The Fourth Affiliated Hospital of Harbin Medical University

Harbin, Heilongjiang, 150001, China
The Institute for Liver Health II dba Arizona Clinical Trials - Mesa

Chandler, Arizona, 85225, United States
The Second Affiliated Hospital of Nanjing Medical University

Nanjing, Jiangsu, 210011, China
The Second Affiliated Hospital of Zhengzhou University

Zhengzhou, Henan, 450014, China
The Second People's Hospital of Hefei

Hefei, Anhui, 230011, China
Thyroid, Endocrinology, and Diabetes

Dallas, Texas, 75208, United States
Tianjin Medical University General Hospital

Tianjin, Tianjin Municipality, 300052, China
Tianjin Medical University Zhu Xianyi Memorial Hospital

Tianjin, Tianjin Municipality, 300134, China
Tokyo-Eki Center-building Clinic

Chuo-ku, Tokyo, 103-0027, Japan
Tsuchiura Medical & Health Care Center

Tsuchiura, Ibaraki, 300-0012, Japan
University Clinical Investigators, Inc.

Tustin, California, 92780, United States
University of Colorado Anschutz Medical Campus

Aurora, Colorado, 80045, United States
Velocity Clinical Research, Dallas

Dallas, Texas, 75230, United States
Velocity Clinical Research, Huntington Park

Huntington Park, California, 90255, United States
Velocity Clinical Research, Westlake

Los Angeles, California, 90057, United States
Victoria Hospital, Bangalore Medical College And Research Institute

Bangalore, Karnataka, 560002, India
Weill Cornell Medical College

New York, New York, 10021, United States
Yokohama Minoru Clinic

Yokohama, Kanagawa, 232-0064, Japan
Yutenji Medical Clinic

Meguro-ku, Tokyo, 153-0053, Japan
Zhejiang Hospital

Hangzhou, Zhejiang, 310013, China

Conditions

Explore the condition pages connected to this study.

OBESITY OVERWEIGHT OVERWEIGHT OR OBESITY