New drug combo could replace ibuprofen for Post-Surgery pain

NCT ID NCT07620665

Recruiting now Symptom relief Sponsor: Gangnam Severance Hospital Source: ClinicalTrials.gov ↗

First seen Jun 27, 2026 · Last updated Jun 27, 2026

Summary

This study compares two pain relief combinations after minimally invasive gallbladder removal: opiranserin plus acetaminophen versus ibuprofen plus acetaminophen. 88 adults will be randomly assigned to one of the two groups. The goal is to see if the new combination controls pain just as well as the standard one.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: opiranserin plus acetaminophen
What this could lead to: If it works, this could offer a new pain relief option after gallbladder surgery that avoids NSAIDs.
What could go wrong: This is a small, early-stage trial with only 88 people, so results may not apply to everyone. It is designed to show non-inferiority, not superiority, so it may not prove opiranserin is better.

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

CHOLECYSTECTOMY, LAPAROSCOPIC CHOLECYSTECTOMY, ROBOTIC MINIMALLY INVASIVE CHOLECYSTECTOMY

New drug combo could replace ibuprofen for Post-Surgery pain

Summary

What this could mean

Get notified about this study

As listed by the trial registrant

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