Can surgery pain be managed without opioids?
NCT ID NCT07786727
First seen Aug 26, 2026 · Last updated Aug 27, 2026 · Updated 1 time
Summary
This trial asks whether avoiding opioids during general anesthesia can still keep pain under control after septoplasty, a surgery to correct a deviated septum. About 150 adults having this elective surgery will be randomly assigned to receive either opioid-free or opioid-based anesthesia, guided by a monitor that tracks the body's pain response. The main focus is on pain scores shortly after surgery, with follow-up checks an hour later to see how recovery compares.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Opioid-free anesthesia (OFA) versus opioid-based general anesthesia
- What this could lead to
- If opioid-free anesthesia works as well as opioids for pain after septoplasty, it could offer a safer alternative that avoids opioid-related side effects and addiction risks.
- What could go wrong
- This is a single trial with 150 patients, so results may not apply broadly. Opioid-free anesthesia might not control pain as effectively for everyone, and the approach is still being tested.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Participants
-
150 people
The number who actually took part.
- Started
-
Jan 2024
- Finished
-
Jun 2025
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
Who is studied
septoplasty patients
- Ages
-
18 years and older
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
1. Inclusion Criteria: * Adult patients aged 18 years or older * American Society of Anesthesiologists (ASA) physical status I-III * Patients scheduled for elective septal surgery under general anesthesia * Ability to provide written informed consent * Ability to understand and use the Numeric Rating Scale (NRS) for postoperative pain assessment 2. Exclusion Criteria: * Patient refusal to participate * Known allergy or hypersensitivity to any of the study medications * Contraindication to general anesthesia * Pre-existing chronic opioid use or chronic pain requiring regular analgesic treatment * Significant psychiatric or neurological disease that could interfere with postoperative pain assessment * Inability to understand or reliably report pain using the Numeric Rating Scale * Pregnancy * Significant hepatic or renal dysfunction * Any medical condition considered by the investigators to make participation inappropriate or unsafe
Get updates
Get notified about this study
Sign up to get updates when this study changes or when new studies for Deviated septum are added.
By submitting, you agree to our Terms of use
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
GH Drama
Drama, Καβάλας, 65403, Greece
More trials for these conditions
Other studies related to the condition(s) this trial covers.
- Can surgery pain be managed without opioids?
- Can skipping opioids speed up recovery from thyroid surgery?
- Opioid-free anesthesia tested in teen scoliosis surgery
- No opioids? new anesthesia approach aims for faster recovery in elderly heart surgery
- Opioid-Free anesthesia: a safer way to wake up after Weight-Loss surgery?
- Pain relief without opioids: safer anesthesia option found