Can surgery pain be managed without opioids?
NCT ID NCT07771049
First seen Aug 18, 2026 · Last updated Aug 18, 2026
Summary
This trial asks whether an opioid-free anesthesia method can control acute pain after laparoscopic colorectal surgery as well as or better than standard opioid-based anesthesia. Adults aged 18 to 90 scheduled for this surgery will be randomly assigned to receive either a combination of non-opioid pain medicines or conventional opioids during and after the procedure. The main goal is to compare pain intensity and the need for extra rescue pain medication in the first 24 hours after surgery, while also tracking side effects, recovery quality, and hospital discharge time.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Opioid-free anesthesia using a combination of dexmedetomidine, lidocaine, ketamine, magnesium sulfate, dexamethasone, and NSAIDs
- What this could lead to
- If it works, this could offer a safer way to manage surgical pain without opioid side effects, potentially speeding recovery and reducing hospital stays.
- What could go wrong
- This is an early-phase trial, so the opioid-free approach may not control pain as effectively as standard opioids, and the drug combination carries its own risks, such as low blood pressure or sedation.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Doctor Jose Molina Orosa
Arrecife, Spain
-
Royo Villanova
Zaragoza, Spain
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