Can Opioid-Free anesthesia improve surgery recovery?
NCT ID NCT06476600
First seen Jul 08, 2026 · Last updated Jul 09, 2026 · Updated 1 time
Summary
This trial tests whether avoiding opioids during anesthesia leads to better recovery after gallbladder surgery. Half of the participants receive standard opioid-based anesthesia, while the other half receive an opioid-free approach using dexmedetomidine. The study measures recovery quality using a patient questionnaire and tracks heart rate and blood pressure during surgery. It includes adults aged 18-65 with low surgical risk.
What this could mean
Our plain-language read of the trial. This is informational only, not medical advice or a prediction.
- Active substance
- Dexmedetomidine and Nalbuphine
- What this could lead to
- If successful, this could show that opioid-free anesthesia provides similar or better recovery without the risks of opioids.
- What could go wrong
- This is a small, early-phase trial with only 42 participants, so results may not apply broadly. Dexmedetomidine can cause side effects like low heart rate or blood pressure.
This is an AI summary of the original study and may miss details. Read our disclaimer.
Study facts
What this study's own registry entry says, in plain language.
- Phase
-
Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
-
42 people
The number who actually took part.
- Started
-
Jul 2024
- Finished
-
Oct 2024
- Lead sponsor
-
Other sponsor
The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
-
18 to 65 years
- Sex
-
Anyone
- Healthy volunteers
-
Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: 1. Signed informed consent from the participant. 2. All patients who are aged between 18 - 65 years. 3. American Society of Anaesthesiologists (ASA) classification of I and II 4. Elective Laparoscopic cholecystectomies. Exclusion Criteria: 1. American Society of Anaesthesiologists (ASA) classification of III and above 2. Non-elective surgery 3. Body Mass Index \> 35 4. Patients with regular prescription of Beta-blockers 5. Pregnant or breastfeeding women 6. Allergy to Opioids and/or other drugs used in the trial. 7. Chronic use of opioids or benzodiazepines 8. Chronic pain patients 9. Patients with cardiovascular, renal, hepatic or central nervous system diseases 10. Patients with psychiatric illness
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
-
Dow university hospital, Dow university of health sciences
Karachi, Sindh, Pakistan
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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