New hope for advanced breast cancer: OPERA-02 trial tests promising drug combo

NCT ID NCT07085767

Recruiting now Disease control Sponsor: Olema Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 15, 2026 · Updated 28 times

Summary

This phase 3 study tests whether a new drug called palazestrant, combined with ribociclib, works better than the standard treatment (letrozole plus ribociclib) for people with a common type of advanced breast cancer (ER+/HER2-). About 1,000 adults who have not had prior treatment for advanced disease will participate. The main goal is to see how long the cancer stays under control.

Disclaimer Read more

This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

Get updates

Get notified about this study

Our safety recommendation!

By submitting, you agree to our Terms of use

Contacts and locations

Show contact details

Study contacts

Contact

Phone: •••-•••-•••• Email: •••••@•••••

Locations

Clinical Trial Site
ACTIVE_NOT_RECRUITING

Hot Springs, Arkansas, 71913, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Santa Barbara, California, 93105, United States
Clinical Trial Site
RECRUITING

Denver, Colorado, 80220, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Peoria, Illinois, 61615, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Ames, Iowa, 50010, United States
Clinical Trial Site
RECRUITING

Scarborough, Maine, 04074, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Annapolis, Maryland, 21401, United States
Clinical Trial Site
RECRUITING

Kansas City, Missouri, 64132, United States
Clinical Trial Site
RECRUITING

Santa Fe, New Mexico, 87505, United States
Clinical Trial Site
RECRUITING

Columbus, Ohio, 43219, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Horsham, Pennsylvania, 19044, United States
Clinical Trial Site
RECRUITING

Sayre, Pennsylvania, 18840, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Knoxville, Tennessee, 37909, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Tennessee City, Tennessee, 37203, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Denton, Texas, 76201, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

El Paso, Texas, 79902, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Houston, Texas, 77024, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

San Antonio, Texas, 78229, United States
Clinical Trial Site
NOT_YET_RECRUITING

Salt Lake City, Utah, 84106, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Olympia, Washington, 98502, United States
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Vancouver, Washington, 98684, United States
Clinical Trial Site
RECRUITING

Sydney, New South Wales, 2109, Australia
Clinical Trial Site
RECRUITING

Waratah, New South Wales, 2298, Australia
Clinical Trial Site
ACTIVE_NOT_RECRUITING

South Brisbane, Queensland, 4101, Australia
Clinical Trial Site
RECRUITING

Adelaide, South Australia, 5000, Australia
Clinical Trial Site
RECRUITING

Clayton, Victoria, 3168, Australia
Clinical Trial Site
RECRUITING

Geelong, Victoria, 3220, Australia
Clinical Trial Site
RECRUITING

Heidelberg, Victoria, 03084, Australia
Clinical Trial Site
RECRUITING

Nedlands, Western Australia, 6009, Australia
Clinical Trial Site
RECRUITING

Toronto, Ontario, M2J 1V1, Canada
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Bobigny, 93000, France
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Athens, Pireas, 18547, Greece
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Thessaloniki, Thessaloniki, 57001, Greece
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Hong Kong, Hong Kong, 999077, Hong Kong
Clinical Trial Site
RECRUITING

Hong Kong, Kowloon, 999077, Hong Kong
Clinical Trial Site
RECRUITING

Hong Kong, Pok Fu Lam, 999077, Hong Kong
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Milan, Milano, 20132, Italy
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Ipoh, Ipoh Perak, 30450, Malaysia
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Kuala Lumpur, Kuala Lumpur, 50586, Malaysia
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
Clinical Trial Site
RECRUITING

George Town, Pulau Pinang, 10450, Malaysia
Clinical Trial Site
RECRUITING

Kota Kinabalu, Sabah, 88996, Malaysia
Clinical Trial Site
RECRUITING

Kuching, Sarawak, 93586, Malaysia
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Petaling Jaya, Selangor, 46050, Malaysia
Clinical Trial Site
RECRUITING

Putrajaya, Wilayah PE, 62250, Malaysia
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Apeldoorn, Gelderland, 7334 DZ, Netherlands
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Rzeszów, Podkarpackie Voivodeship, 35-055, Poland
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Rzeszów, Podkarpackie Voivodeship, 35-922, Poland
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Brzozów, Woj Podkarpackie, 36-200, Poland
Clinical Trial Site
RECRUITING

Cluj-Napoca, Cluj, 400641, Romania
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Iași, Iaşi, 700106, Romania
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Timișoara, Timiș County, 300239, Romania
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Busan, Busan Metropolitan City, 49201, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Daegu, Daegu Metropolitan City, 41404, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Goyang-si, Gyeonggi-do, 10408, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Seongnam-si, Gyeonggi-do, 13620, South Korea
Clinical Trial Site
RECRUITING

Suwon, Gyeonggi-do, 16247, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Yongin-si, Gyeonggi-do, 16499, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Seoul, Seoul, 02841, South Korea
Clinical Trial Site
RECRUITING

Seoul, Seoul, 03080, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Seoul, Seoul, 03722, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Seoul, Seoul Special City, 05505, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Seoul, Seoul Special City, 08308, South Korea
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Alicante, Alicante, 3010, Spain
Clinical Trial Site
RECRUITING

Barcelona, Barcelona, 08028, Spain
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Barcelona, Barcelona, 08036, Spain
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Granada, Granada, 18012, Spain
Clinical Trial Site
RECRUITING

Madrid, Madrid, 28040, Spain
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Murcia, Murcia, 30120, Spain
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Valencia, Valencia, 46010, Spain
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Chang-hua, Chang Hua, 50006, Taiwan
Clinical Trial Site
RECRUITING

Kaohsiung City, Sanmin, 80756, Taiwan
Clinical Trial Site
RECRUITING

Taipei, Special Municipality, 11217, Taiwan
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Taipei, Special Municipality, 11490, Taiwan
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Taipei, Taipei City, 100, Taiwan
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Taipei, Taipei City, 10449, Taiwan
Clinical Trial Site
RECRUITING

Bangkok, Bangkok, 10700, Thailand
Clinical Trial Site
RECRUITING

Dusit, Bangkok, 10300, Thailand
Clinical Trial Site
RECRUITING

Ban Phaeo, Changwat Samut Sakhon, 74120, Thailand
Clinical Trial Site
RECRUITING

Hat Yai, Changwat Songkhla, 90110, Thailand
Clinical Trial Site
RECRUITING

Chiang Mai, Chiang Mai, 50200, Thailand
Clinical Trial Site
RECRUITING

Brighton, England, BN2 5BE, United Kingdom
Clinical Trial Site
ACTIVE_NOT_RECRUITING

London, England, WC1E 6AG, United Kingdom
Clinical Trial Site
ACTIVE_NOT_RECRUITING

London, Greater London, EC1M 6BQ, United Kingdom
Clinical Trial Site
ACTIVE_NOT_RECRUITING

Guildford, Surrey, GU2 7XX, United Kingdom

Conditions

Explore the condition pages connected to this study.

BREAST CANCER ER POSITIVE BREAST CANCER ER-POSITIVE BREAST CANCER HER2-NEGATIVE BREAST CARCINOMA LOCALLY ADVANCED BREAST CANCER METASTATIC BREAST CANCER