New hope for kids with deadly brain tumors: experimental drug ONC206 enters human testing
NCT ID NCT04732065
First seen Mar 09, 2026 · Last updated Jun 18, 2026 · Updated 15 times
Summary
This study tests an experimental drug called ONC206, alone or with radiation, in children and young adults with diffuse midline glioma (a tough-to-treat brain tumor) or other recurrent brain cancers. The goal is to find the best dose and see if it's safe. The drug works by stressing cancer cells so they die, while leaving healthy cells alone. Up to 208 participants will be enrolled.
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Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Study contacts
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Contact
Phone: •••-•••-•••• Email: •••••@•••••
Locations
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Children's Hospital of Philadelphia
RECRUITINGPhiladelphia, Pennsylvania, 19104, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Children's National Hospital
RECRUITINGWashington D.C., District of Columbia, 20010, United States
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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Emory University
RECRUITINGAtlanta, Georgia, 30322, United States
Contact Email: •••••@•••••
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Princess Máxima Center for Pediatric Oncology
RECRUITINGUtrecht, 3584, Netherlands
Contact Phone: •••-•••-••••
Contact Email: •••••@•••••
Contact
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The University Children's Hospital in Zurich
RECRUITINGZurich, Canton of Zurich, 8032, Switzerland
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
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University of California, San Francisco
RECRUITINGSan Francisco, California, 94143, United States
Contact Email: •••••@•••••
Contact Phone: •••-•••-•••• Email: •••••@•••••
Contact
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University of Michigan
RECRUITINGAnn Arbor, Michigan, 48109, United States
Contact
Contact Email: •••••@•••••
Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.