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Personal healthcare: maxmising the benefits of exercise by understanding the mechanisms of metabolic compensation

NCT ID NCT07893249

Sponsor: Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences Source: ClinicalTrials.gov ↗

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First seen Oct 23, 2026 · Last updated Oct 23, 2026

Summary

This prospective, single-arm interventional study will investigate why adults receiving the same prescribed dose and relative intensity of exercise show divergent changes in energy balance, body weight, and body composition. A total of 150 sedentary Chinese adults aged 18-40 years with overweight or obesity will complete a 12-week, supervised treadmill exercise programme. Exercise will be performed five times per week at an intensity corresponding to 60% of each participant's measured maximal oxygen uptake. Prescribed exercise energy expenditure will increase progressively from 150 kcal per session in Weeks 1-4 to 250 kcal per session in Weeks 5-8 and 350 kcal per session in Weeks 9-12. The primary objective is to quantify inter-individual variability in energy compensation after the standardized intervention. Detailed measurements will characterize total and resting energy expenditure, energy intake, appetite, physical activity, body composition, glucose dynamics, cardiorespiratory fitness, brain responses to food-related stimuli, and molecular phenotypes. Multi-omics analyses will include gut microbiome, metabolomic, proteomic, extracellular-vesicle, peripheral blood mononuclear cell, and transcriptomic assessments. The study will explore physiological, behavioral, and molecular factors associated with divergent compensatory responses. No randomized comparator group is included; therefore, causal comparisons between exercise and non-exercise conditions are outside the study scope.

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Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

About 150 people

The number the study aims to enrol. It can still change while the study runs.

Expected to start

Oct 2026

An estimate. Start dates often move.

Expected to finish

Dec 2030

An estimate. End dates often move.

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 40 years

Sex

Anyone

Healthy volunteers

Accepted

You do not need to have the condition being studied to take part.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Sedentary individuals * BMI ≥ 24 kg/m2 * Chinese male and female adults * Normal electrocardiogram (ECG) Exclusion Criteria: * Individuals who have undergone major surgery within the past 6 months (tooth extraction excluded); * Individuals with cardiovascular diseases (e.g., hypertension) and severe * metabolic diseases requiring continuous medication (e.g., diabetes); * Exercise-induced injuries, including joint diseases, fractures, etc.; * Individuals with infectious diseases, such as HIV/AIDS, tuberculosis, malaria, etc.; * Psychiatric and neurological disorders, such as anorexia nervosa, etc.; * Individuals who have attempted weight loss or weight gain through various means within the past three months; * Individuals who are pregnant, breastfeeding, or planning to become pregnant during the study period * Individuals with claustrophobia or metallic implants in the body which are incompatible with MRI measurements * Individuals who have used antibiotics, probiotics, oral laxatives, etc., within eight weeks; * Individuals with a history of hemophobia or needle phobia. * Individuals who have been drinking deuterium depleted water which is incompatible with the DLW measures.

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Conditions

The condition(s) this trial relates to.

Motor Activity Obesity obesity disorder Overweight Sedentary Behavior

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Obesity Overweight Physical inactivity

How to take part

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  1. The places running it

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  2. The official record

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  3. A doctor treating you

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Contacts and locations

Locations

  • Shenzhen Institutes of Advanced Technology ,Chinese Academy of Sciences

    Shenzhen, Guangdong, China

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