A controlled study to evaluate the effects of a supplement on weight loss, blood sugar, and appetite suppression
NCT ID NCT07889570
First seen Oct 22, 2026 ยท Last updated Oct 22, 2026
Summary
This is a randomized, controlled, hybrid clinical trial evaluating the effects of the Evolv GLP-1 supplement on weight loss, blood sugar regulation, and appetite suppression over 12 weeks. Participants are randomized to either the intervention group (8 capsules daily) or a control group receiving standardized healthy eating guidance from the American Diabetes Association. The study enrolls 98 male and female participants aged 18 and older with a BMI of 25-29.9 kg/m2. Primary endpoints include Hemoglobin A1c (HgbA1c) measured via bloodwork at Baseline, Week 6, and Week 12, as well as body weight and waist circumference measurements collected at Baseline, Week 4, Week 6, Week 8, and Week 12. Secondary endpoints capture participant perceptions of appetite suppression, weight loss, blood sugar, and overall well-being via self-reported questionnaires at the same time points.
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Study facts
What this study's own registry entry says, in plain language.
- Phase
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Not a phased trial
Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.
- Participants
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98 people
The number who actually took part.
- Started
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Apr 2026
- Finished
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Jul 2026
- Lead sponsor
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A company
The lead sponsor is a pharmaceutical, biotech, or medical-device company.
Who can take part
This study's own entry requirements. Only the study team can say for certain whether you qualify.
- Ages
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18 years and older
- Sex
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Anyone
- Healthy volunteers
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Accepted
You do not need to have the condition being studied to take part.
Show the full entry requirements Hide the full entry requirements
Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.
Inclusion Criteria: * Be male or female * Be aged 18+ * BMI of 25-29.9 kg/m2 * Anyone with concerns regarding all of the following for the past 12 weeks: weight management and food cravings and/or appetite management * Must not be living with any uncontrolled chronic disease * Not currently taking, and not planning to take for the duration of the test period, any products, prescription medications, herbal remedies, over-the-counter medications, or supplements that target blood sugar regulation, weight, or appetite * Willing to maintain their current sleep schedule and activity level for the duration of the study * Resides in the United States * Not currently partaking in another research study and will not be partaking in any other research study for the next 12 weeks or at any point during this study's duration Exclusion Criteria: * Diagnosed with Type 1 diabetes, any metabolic or endocrine disorder, or any disorder that affects blood sugars (e.g., hypothyroidism, Hashimoto's thyroiditis) * Diagnosed with Type 2 diabetes mellitus (T2DM) and have been prescribed metformin, insulin, Sulfonylureas, Meglitinides, SGLT2 inhibitors and/or GLP-1 medications including Wegovy, Ozempic, Rybelsus, Saxenda, Victoza, Zepbound, Byetta, Bydureon, Trulicity, or Adlyxin * Current use or past history of use within the last 2 months (8 weeks) of corticosteroids including Deltasone, Orapred, Prelone, Medrol, Qvar, Celestone, Decadron, Cortef, or Kenalog * Current use or past history of use within the last 2 months (8 weeks) of immunosuppressants including Tacrolimus (Prograf), Cyclosporine (Neoral), or Sirolimus (Rapamune) * Anyone who has been treated with any antibiotic or antifungal prescription medication in the last 2 months (8 weeks) * Anyone with pre-existing chronic conditions that would prevent participants from adhering to the protocol, including cancer, liver, and psychiatric disorders * Is currently undergoing or planning to undergo any significant medical procedures in the next six months * Anyone who has undergone any surgeries or invasive treatments in the last six months, or has any planned during the study period * Has had any major illness in the last three months * Anyone with known severe allergic reactions, including those requiring the use of an Epi-pen * Anyone with any allergies or sensitivities to any of the study product ingredients * Any women who are pregnant, breastfeeding, or trying to conceive (or who will be at any point during the study period) * Heavy drinkers or drug users (a heavy drinker is considered to be a woman who drinks 8 or more alcoholic drinks per week or a man who drinks 15 or more alcoholic drinks per week) * Anyone unwilling to follow the study protocol * Anyone with a history of substance abuse * Anyone who is currently a smoker or has been a smoker in the past 3 months
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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Citruslabs
Las Vegas, Nevada, 89118, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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