New depression pill shows promise in large trial

NCT ID NCT06058013

Ongoing Symptom relief Sponsor: Neumora Therapeutics, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated Apr 30, 2026 · Updated 25 times

Summary

This study tests an experimental oral medication, NMRA-335140, against a placebo in 332 adults with major depressive disorder. Over 6 weeks, researchers measure changes in depression symptoms using standard rating scales. The goal is to see if the drug can safely reduce depression severity better than a placebo.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Neumora Investigator Site

Encino, California, 91316, United States
Neumora Investigator Site

Garden Grove, California, 92845, United States
Neumora Investigator Site

Los Alamitos, California, 90720, United States
Neumora Investigator Site

Newport Beach, California, 92660, United States
Neumora Investigator Site

Orange, California, 92868, United States
Neumora Investigator Site

Santa Ana, California, 92704, United States
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Norwalk, Connecticut, 06851, United States
Neumora Investigator Site

Bradenton, Florida, 34205, United States
Neumora Investigator Site

Hollywood, Florida, 33024, United States
Neumora Investigator Site

Homestead, Florida, 33032, United States
Neumora Investigator Site

Lauderhill, Florida, 33161, United States
Neumora Investigator Site

Maitland, Florida, 32751, United States
Neumora Investigator Site

Miami, Florida, 33126, United States
Neumora Investigator Site

Miami, Florida, 33133, United States
Neumora Investigator Site

Miami, Florida, 33137, United States
Neumora Investigator Site

Miami, Florida, 33186, United States
Neumora Investigator Site

Miami Lakes, Florida, 33014, United States
Neumora Investigator Site

Miami Lakes, Florida, 33016, United States
Neumora Investigator Site

Orlando, Florida, 32801, United States
Neumora Investigator Site

Orlando, Florida, 32803, United States
Neumora Investigator Site

Orlando, Florida, 32807, United States
Neumora Investigator Site

Pinellas Park, Florida, 33782, United States
Neumora Investigator Site

Pompano Beach, Florida, 33060, United States
Neumora Investigator Site

Tampa, Florida, 33607, United States
Neumora Investigator Site

Tampa, Florida, 33613, United States
Neumora Investigator Site

Atlanta, Georgia, 30318, United States
Neumora Investigator Site

Atlanta, Georgia, 30328, United States
Neumora Investigator Site

Atlanta, Georgia, 30338, United States
Neumora Investigator Site

Marrero, Louisiana, 70072, United States
Neumora Investigator Site

New Orleans, Louisiana, 70115, United States
Neumora Investigator Site

Baltimore, Maryland, 21208, United States
Neumora Investigator Site

Towson, Maryland, 21204, United States
Neumora Investigator Site

Boston, Massachusetts, 02116, United States
Neumora Investigator Site

Boston, Massachusetts, 02131, United States
Neumora Investigator Site

Watertown, Massachusetts, 02472, United States
Neumora Investigator Site

Mankato, Minnesota, 56001, United States
Neumora Investigator Site

Princeton, New Jersey, 08540, United States
Neumora Investigator Site

Toms River, New Jersey, 08755, United States
Neumora Investigator Site

Albuquerque, New Mexico, 87109, United States
Neumora Investigator Site

Buffalo, New York, 14215, United States
Neumora Investigator Site

Inwood, New York, 11096, United States
Neumora Investigator Site

New York, New York, 10017, United States
Neumora Investigator Site

The Bronx, New York, 10461, United States
Neumora Investigator Site

Monroe, North Carolina, 28112, United States
Neumora Investigator Site

North Canton, Ohio, 44720, United States
Neumora Investigator Site

Oklahoma City, Oklahoma, 73118, United States
Neumora Investigator Site

Philadelphia, Pennsylvania, 19104, United States
Neumora Investigator Site

North Charleston, South Carolina, 29405, United States
Neumora Investigator Site

Memphis, Tennessee, 38119, United States
Neumora Investigator Site

Austin, Texas, 78737, United States
Neumora Investigator Site

Dallas, Texas, 75243, United States
Neumora Investigator Site

Houston, Texas, 77030, United States
Neumora Investigator Site

Bellevue, Washington, 98007, United States
Neumora Investigator Site

Everett, Washington, 98201, United States
Neumora Investigator Site

Curitiba, Paraná, 80240280, Brazil
Neumora Investigator Site

Porto Alegre, Rio Grande do Sul, 90610-001, Brazil
Neumora Investigator Site

Santa Cecília, São Paulo, 01228-000, Brazil
Neumora Investigator Site

São Bernardo do Campo, São Paulo, 09726150, Brazil
Neumora Investigator Site

São José do Rio Preto, São Paulo, 15090-000, Brazil
Neumora Investigator Site

Rio de Janeiro, 22270-060, Brazil
Neumora Investigator Site

São Paulo, 01236030, Brazil
Neumora Investigator Site

Kelowna, British Columbia, V1Y 1Z9, Canada
Neumora Investigator Site

Hamilton, Ontario, L8S 1B7, Canada
Neumora Investigator Site

Toronto, Ontario, L5L 1W8, Canada
Neumora Investigator Site

Toronto, Ontario, M5S 1M2, Canada
Neumora Investigator Site

Santiago, Santiago Metropolitan, 7500710, Chile
Neumora Investigator Site

Santiago, Santiago Metropolitan, 8330034, Chile
Neumora Investigator Site

Antofagasta, 1270244, Chile
Neumora Investigator Site

Santiago, 7560356, Chile
Neumora Investigator Site

Santiago, 7561282, Chile
Neumora Investigator Site#1

Tampa, Florida, 33613, United States
Neumora Investigator Sites

Miami, Florida, 33122, United States
Neumora Investigator site

Edmond, Oklahoma, 73013, United States
Neumora Investigator site

Markham, Ontario, L3R 1A3, Canada

Conditions

Explore the condition pages connected to this study.

MAJOR DEPRESSIVE DISORDER