New male birth control pill could work in minutes

NCT ID NCT07393334

Recruiting now Disease control Sponsor: Next Life Sciences Source: ClinicalTrials.gov ↗

First seen Jun 25, 2026 · Last updated Jun 27, 2026 · Updated 1 time

Summary

This study tests a new non-hormonal male contraceptive called NLS-133, taken just before sex to reduce sperm count and semen volume. Ten healthy men will receive the drug, an active control, or a placebo in random order. The goal is to see if it safely and effectively lowers sperm count and motility.

What this could mean

Our plain-language read of the trial. This is informational only — not medical advice or a prediction.

Active substance: NLS-133 (combination of two FDA-approved drugs)
What this could lead to: If it works, this could lead to a new non-hormonal, on-demand male contraceptive pill.
What could go wrong: This is a very small early-phase trial with only 10 men, so results may not apply widely. The drug is taken just before sex, so effectiveness and safety are still uncertain.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Get updates

Get notified about this study

Sign up to get updates when this study changes or when new studies for MALE CONTRACEPTION are added.

Our safety recommendation!

By submitting, you agree to our Terms of use

As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

MALE CONTRACEPTION SEMEN VOLUME SPERM MOTILITY

Contacts and locations

Locations

Population Center for Research in Human Reproduction and Departments of Medicine, University of Washington
RECRUITING

Seattle, Washington, 98195, United States

More trials for these conditions

Other studies related to the condition(s) this trial covers.