Triple-Drug cocktail takes on advanced melanoma
NCT ID NCT04091750
First seen Jun 26, 2026 · Last updated Jun 27, 2026 · Updated 1 time
Summary
This phase II study tests a combination of three drugs—nivolumab, ipilimumab, and cabozantinib—in 14 people with advanced melanoma that cannot be surgically removed. Participants receive the drugs for up to two years. The main goal is to see how long the cancer stays under control. The study is active but no longer recruiting.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- nivolumab (Opdivo), ipilimumab (Yervoy), and cabozantinib (Cabometyx)
- What this could lead to
- If successful, this combination could offer a new treatment option for people with advanced melanoma that cannot be removed by surgery.
- What could go wrong
- This is a very small, early-phase study with only 14 participants, so results may not apply to everyone. The drug combination can cause significant side effects, and it is not yet known if it works better than existing treatments.
This is an AI summary of the original study and may miss details. Read our disclaimer.
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Conditions
The condition(s) this trial relates to.
As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
Contacts and locations
Locations
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John Theurer Cancer Center at Hackensack University Medical Center
Hackensack, New Jersey, 07601, United States
-
Lombardi Comprehensive Cancer Center
Washington D.C., District of Columbia, 20007, United States
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Medstar Franklin Square Medical Center, Harry and Jeanette Weinberg Cancer Institute
Baltimore, Maryland, 21237, United States
More trials for these conditions
Other studies related to the condition(s) this trial covers.
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- Can your genes predict your melanoma risk?