New drug combo shows promise in keeping High-Risk prostate cancer at bay

NCT ID NCT04037254

Completed Disease control Sponsor: NRG Oncology Source: ClinicalTrials.gov ↗

First seen Apr 09, 2026 · Last updated May 01, 2026 · Updated 1 time

Summary

This study looked at adding a drug called niraparib to the usual treatment (radiation plus hormone therapy) for men with high-risk prostate cancer. The goal was to see if the combination could lower the chance of the cancer growing or coming back. Twenty-two men took part, and researchers tracked their PSA levels for two years to check if the cancer stayed away.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Locations

Alton Memorial Hospital

Alton, Illinois, 62002, United States
Arthur J E Child Comprehensive Cancer Centre

Calgary, Alberta, T2N 5G2, Canada
AtlantiCare Health Park-Cape May Court House

Cape May Court House, New Jersey, 08210, United States
AtlantiCare Surgery Center

Egg Harbor, New Jersey, 08234, United States
Banner MD Anderson Cancer Center

Gilbert, Arizona, 85234, United States
Benefis Sletten Cancer Institute

Great Falls, Montana, 59405, United States
CTCA at Southeastern Regional Medical Center

Newnan, Georgia, 30265, United States
Carle Cancer Center

Urbana, Illinois, 61801, United States
Case Western Reserve University

Cleveland, Ohio, 44106, United States
Cedars Sinai Medical Center

Los Angeles, California, 90048, United States
Central Maryland Radiation Oncology in Howard County

Columbia, Maryland, 21044, United States
Christiana Care Health System-Concord Health Center

Chadds Ford, Pennsylvania, 19317, United States
City of Hope Comprehensive Cancer Center

Duarte, California, 91010, United States
City of Hope Upland

Upland, California, 91786, United States
Drexel Town Square Health Center

Oak Creek, Wisconsin, 53154, United States
Eastern Regional Medical Center

Philadelphia, Pennsylvania, 19124, United States
Emory Saint Joseph's Hospital

Atlanta, Georgia, 30342, United States
Emory University Hospital/Winship Cancer Institute

Atlanta, Georgia, 30322, United States
Fremont - Rideout Cancer Center

Marysville, California, 95901, United States
Froedtert Menomonee Falls Hospital

Menomonee Falls, Wisconsin, 53051, United States
Froedtert West Bend Hospital/Kraemer Cancer Center

West Bend, Wisconsin, 53095, United States
Geisinger Medical Center

Danville, Pennsylvania, 17822, United States
Geisinger Medical Oncology-Lewisburg

Lewisburg, Pennsylvania, 17837, United States
Geisinger Wyoming Valley/Henry Cancer Center

Wilkes-Barre, Pennsylvania, 18711, United States
George Washington University Medical Center

Washington D.C., District of Columbia, 20037, United States
Grady Health System

Atlanta, Georgia, 30303, United States
Helen F Graham Cancer Center

Newark, Delaware, 19713, United States
Henry Ford Cancer Institute-Downriver

Brownstown, Michigan, 48183, United States
Henry Ford Hospital

Detroit, Michigan, 48202, United States
Henry Ford Macomb Health Center - Shelby Township

Shelby, Michigan, 48315, United States
Henry Ford Macomb Hospital-Clinton Township

Clinton Township, Michigan, 48038, United States
Henry Ford Medical Center-Columbus

Novi, Michigan, 48377, United States
Henry Ford Medical Center-Fairlane

Dearborn, Michigan, 48126, United States
Henry Ford West Bloomfield Hospital

West Bloomfield, Michigan, 48322, United States
Highland Hospital

Rochester, New York, 14620, United States
Holy Name Hospital

Teaneck, New Jersey, 07666, United States
Karmanos Cancer Institute at McLaren Greater Lansing

Lansing, Michigan, 48910, United States
Lewistown Hospital

Lewistown, Pennsylvania, 17044, United States
Massachusetts General Hospital Cancer Center

Boston, Massachusetts, 02114, United States
McLaren Cancer Institute-Bay City

Bay City, Michigan, 48706, United States
McLaren Cancer Institute-Clarkston

Clarkston, Michigan, 48346, United States
McLaren Cancer Institute-Flint

Flint, Michigan, 48532, United States
McLaren Cancer Institute-Lapeer Region

Lapeer, Michigan, 48446, United States
McLaren Cancer Institute-Macomb

Mount Clemens, Michigan, 48043, United States
McLaren Cancer Institute-Northern Michigan

Petoskey, Michigan, 49770, United States
McLaren-Port Huron

Port Huron, Michigan, 48060, United States
Medical College of Wisconsin

Milwaukee, Wisconsin, 53226, United States
Medical Oncology Hematology Consultants PA

Newark, Delaware, 19713, United States
Medical University of South Carolina

Charleston, South Carolina, 29425, United States
Mid-Michigan Physicians-Lansing

Lansing, Michigan, 48912, United States
Northwestern University

Chicago, Illinois, 60611, United States
Penn State Milton S Hershey Medical Center

Hershey, Pennsylvania, 17033-0850, United States
Prisma Health Cancer Institute - Eastside

Greenville, South Carolina, 29615, United States
Prisma Health Cancer Institute - Faris

Greenville, South Carolina, 29605, United States
Prisma Health Cancer Institute - Greer

Greer, South Carolina, 29650, United States
Prisma Health Cancer Institute - Seneca

Seneca, South Carolina, 29672, United States
ProHealth Oconomowoc Memorial Hospital

Oconomowoc, Wisconsin, 53066, United States
Roswell Park Cancer Institute

Buffalo, New York, 14263, United States
Rush MD Anderson Cancer Center

Chicago, Illinois, 60612, United States
Rutgers New Jersey Medical School

Newark, New Jersey, 07101, United States
Saint Francis Cancer Center

Greenville, South Carolina, 29607, United States
Self Regional Healthcare

Greenwood, South Carolina, 29646, United States
Singh and Arora Hematology Oncology PC

Flint, Michigan, 48532, United States
Siteman Cancer Center at Saint Peters Hospital

City of Saint Peters, Missouri, 63376, United States
Siteman Cancer Center at West County Hospital

Creve Coeur, Missouri, 63141, United States
Siteman Cancer Center-South County

St Louis, Missouri, 63129, United States
Stony Brook University Medical Center

Stony Brook, New York, 11794, United States
Summa Health Medina Medical Center

Medina, Ohio, 44256, United States
Summa Health System - Akron Campus

Akron, Ohio, 44304, United States
Summa Health System - Barberton Campus

Barberton, Ohio, 44203, United States
The New York Hospital Medical Center of Queens

Flushing, New York, 11355, United States
UM Baltimore Washington Medical Center/Tate Cancer Center

Glen Burnie, Maryland, 21061, United States
UPMC-Shadyside Hospital

Pittsburgh, Pennsylvania, 15232, United States
UW Cancer Center at ProHealth Care

Waukesha, Wisconsin, 53188, United States
University of Arizona Cancer Center-North Campus

Tucson, Arizona, 85719, United States
University of Arizona Cancer Center-Orange Grove Campus

Tucson, Arizona, 85704, United States
University of California Davis Comprehensive Cancer Center

Sacramento, California, 95817, United States
University of Cincinnati Cancer Center-UC Medical Center

Cincinnati, Ohio, 45219, United States
University of Cincinnati Cancer Center-West Chester

West Chester, Ohio, 45069, United States
University of Iowa/Holden Comprehensive Cancer Center

Iowa City, Iowa, 52242, United States
University of Kansas Cancer Center

Kansas City, Kansas, 66160, United States
University of Kansas Cancer Center - Lee's Summit

Lee's Summit, Missouri, 64064, United States
University of Kansas Cancer Center - North

Kansas City, Missouri, 64154, United States
University of Kansas Cancer Center-Overland Park

Overland Park, Kansas, 66210, United States
University of Kansas Hospital-Westwood Cancer Center

Westwood, Kansas, 66205, United States
University of Maryland/Greenebaum Cancer Center

Baltimore, Maryland, 21201, United States
University of Mississippi Medical Center

Jackson, Mississippi, 39216, United States
University of Oklahoma Health Sciences Center

Oklahoma City, Oklahoma, 73104, United States
University of Pittsburgh Cancer Institute (UPCI)

Pittsburgh, Pennsylvania, 15232, United States
University of Rochester

Rochester, New York, 14642, United States
Washington University School of Medicine

St Louis, Missouri, 63110, United States
Wayne State University/Karmanos Cancer Institute

Detroit, Michigan, 48201, United States
Weisberg Cancer Treatment Center

Farmington Hills, Michigan, 48334, United States
West Virginia University Healthcare

Morgantown, West Virginia, 26506, United States
Zablocki Veterans Administration Medical Center

Milwaukee, Wisconsin, 53295, United States

Conditions

Explore the condition pages connected to this study.

PROSTATE ADENOCARCINOMA STAGE IIC PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8 STAGE III PROSTATE CANCER AJCC V8 STAGE IIIA PROSTATE CANCER AJCC V8 STAGE IIIA PROSTATE CANCER AJCC V8 STAGE IIIB PROSTATE CANCER AJCC V8 STAGE IIIB PROSTATE CANCER AJCC V8 STAGE IIIC PROSTATE CANCER AJCC V8 STAGE IIIC PROSTATE CANCER AJCC V8 STAGE IVA PROSTATE CANCER AJCC V8 STAGE IVA PROSTATE CANCER AJCC V8