First human trial tests new drug duo against aggressive cancers
NCT ID NCT05372640
Summary
This early-stage study aims to find the safest dose of two oral drugs—ZEN003694 and abemaciclib—when given together to patients with advanced cancers that have spread or cannot be removed by surgery. The trial will enroll about 45 adults and teens (12+) with specific cancers, including a rare and aggressive type called NUT carcinoma, as well as breast cancer and other solid tumors. Researchers will monitor side effects closely and see if the drug combination can help shrink or stabilize tumors.
This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes NO responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.
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Contacts and locations
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Locations
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Dana-Farber Cancer Institute
RECRUITINGBoston, Massachusetts, 02215, United States
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Keck Medicine of USC Koreatown
RECRUITINGLos Angeles, California, 90020, United States
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Los Angeles General Medical Center
RECRUITINGLos Angeles, California, 90033, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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M D Anderson Cancer Center
RECRUITINGHouston, Texas, 77030, United States
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Contact Phone: •••-•••-•••• Email: •••••@•••••
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USC / Norris Comprehensive Cancer Center
RECRUITINGLos Angeles, California, 90033, United States
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USC Norris Oncology/Hematology-Newport Beach
RECRUITINGNewport Beach, California, 92663, United States
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University of Pittsburgh Cancer Institute (UPCI)
RECRUITINGPittsburgh, Pennsylvania, 15232, United States
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Contact Phone: •••-•••-••••
Conditions
Explore the condition pages connected to this study.