New hope for advanced breast cancer: phase 3 trial launches

NCT ID NCT07085767

Recruiting now Disease control Sponsor: Olema Pharmaceuticals, Inc. Source: ClinicalTrials.gov ↗

First seen Nov 01, 2025 · Last updated May 22, 2026 · Updated 31 times

Summary

This study tests a new drug, palazestrant, combined with ribociclib against the standard letrozole with ribociclib for people with ER+, HER2- advanced breast cancer that has not been treated before. About 1,000 adults with locally advanced or metastatic breast cancer will take part. The goal is to see if the new combination helps delay cancer growth and improve survival.

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This is a summary of the original study . Summaries may miss details or leave out important information. Before applying or accepting participation, make sure you have read and understood the full study. Curemydisease.com takes no responsibility whatsoever for anything missed, misunderstood, or acted upon as a result of our summary — we know it does not capture everything.

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Contacts and locations

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Study contacts

Contact

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Locations

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Hot Springs, Arkansas, 71913, United States
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Beverly Hills, California, 90211, United States
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Santa Barbara, California, 93105, United States
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Aurora, Colorado, 80045, United States
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Denver, Colorado, 80220, United States
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Honolulu, Hawaii, 96813, United States
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Peoria, Illinois, 61615, United States
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Ames, Iowa, 50010, United States
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Scarborough, Maine, 04074, United States
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Annapolis, Maryland, 21401, United States
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Minneapolis, Minnesota, 55404, United States
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Kansas City, Missouri, 64132, United States
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Santa Fe, New Mexico, 87505, United States
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Cincinnati, Ohio, 45245, United States
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Columbus, Ohio, 43219, United States
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Horsham, Pennsylvania, 19044, United States
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Sayre, Pennsylvania, 18840, United States
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Knoxville, Tennessee, 37909, United States
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Tennessee City, Tennessee, 37203, United States
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Denton, Texas, 76201, United States
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El Paso, Texas, 79902, United States
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Houston, Texas, 77024, United States
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San Antonio, Texas, 78229, United States
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Salt Lake City, Utah, 84106, United States
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Fort Belvoir, Virginia, 22060, United States
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Norfolk, Virginia, 23502, United States
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Olympia, Washington, 98502, United States
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Vancouver, Washington, 98684, United States
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Sydney, New South Wales, 2109, Australia
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Waratah, New South Wales, 2298, Australia
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South Brisbane, Queensland, 4101, Australia
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Adelaide, South Australia, 5000, Australia
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Clayton, Victoria, 3168, Australia
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Geelong, Victoria, 3220, Australia
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Heidelberg, Victoria, 03084, Australia
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Nedlands, Western Australia, 6009, Australia
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Linz, Upper Austria, 4010, Austria
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Kortrijk, Flanders, 8500, Belgium
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Charleroi, Wallonia, 6060, Belgium
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Toronto, Ontario, M2J 1V1, Canada
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Prague, Prague, 150 06, Czechia
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Zlín, Zlín, 762 75, Czechia
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Pierre-Bénite, Auvergne-Rhône-Alpes, 69310, France
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Brest, Brittany Region, 29609, France
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Besançon, Doubs, 25000, France
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Montpellier, Hérault, 34070, France
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Toulouse, Occitanie, 31059, France
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Bobigny, 93000, France
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Torgau, Saxony, 04860, Germany
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Athens, Pireas, 18547, Greece
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Thessaloniki, Thessaloniki, 57001, Greece
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Hong Kong, Hong Kong, 999077, Hong Kong
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Hong Kong, Kowloon, 999077, Hong Kong
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Hong Kong, Pok Fu Lam, 999077, Hong Kong
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Kecskemét, Bács-Kiskun county, 6000, Hungary
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Debrecen, Hajdú-Bihar, 4032, Hungary
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Bologna, Emilia-Romagna, 40138, Italy
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Genoa, Liguria, 16132, Italy
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Milan, Milano, 20132, Italy
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Prato, Tuscany, 59100, Italy
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Milan, Varese, 21100, Italy
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Ipoh, Ipoh Perak, 30450, Malaysia
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Kuala Lumpur, Kuala Lumpur, 50586, Malaysia
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Kuala Lumpur, Kuala Lumpur, 59100, Malaysia
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George Town, Pulau Pinang, 10450, Malaysia
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Kota Kinabalu, Sabah, 88996, Malaysia
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Kuching, Sarawak, 93586, Malaysia
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Petaling Jaya, Selangor, 46050, Malaysia
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Putrajaya, Wilayah PE, 62250, Malaysia
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Apeldoorn, Gelderland, 7334 DZ, Netherlands
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Amsterdam, North Holland, 1081 HV, Netherlands
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Rzeszów, Podkarpackie Voivodeship, 35-055, Poland
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Rzeszów, Podkarpackie Voivodeship, 35-922, Poland
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Brzozów, Woj Podkarpackie, 36-200, Poland
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Lodz, Łódź Voivodeship, 90-302, Poland
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Porto, Porto District, 4464-513, Portugal
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Bucharest, Bucharest, 11171, Romania
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Cluj-Napoca, Cluj, 400641, Romania
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Ovidiu, Constanța County, 905900, Romania
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Craiova, Dolj, 200542, Romania
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Iași, Iaşi, 700106, Romania
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Timișoara, Timiș County, 300239, Romania
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Busan, Busan Metropolitan City, 49201, South Korea
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Daegu, Daegu Metropolitan City, 41404, South Korea
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Goyang-si, Gyeonggi-do, 10408, South Korea
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Seongnam-si, Gyeonggi-do, 13620, South Korea
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Suwon, Gyeonggi-do, 16247, South Korea
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Yongin-si, Gyeonggi-do, 16499, South Korea
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Seoul, Seoul, 02841, South Korea
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Seoul, Seoul, 03722, South Korea
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Seoul, Seoul Special City, 05505, South Korea
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Seoul, Seoul Special City, 08308, South Korea
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Alicante, Alicante, 3010, Spain
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Barcelona, Barcelona, 08028, Spain
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Barcelona, Barcelona, 08035, Spain
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Barcelona, Barcelona, 08036, Spain
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Granada, Granada, 18012, Spain
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Lleida, Lleida, 25198, Spain
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Madrid, Madrid, 28007, Spain
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Madrid, Madrid, 28040, Spain
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Madrid, Madrid, 28046, Spain
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Madrid, Madrid, 28050, Spain
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Murcia, Murcia, 30120, Spain
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Seville, Sevilla, 41009, Spain
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Valencia, Valencia, 46010, Spain
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Zaragoza, Zaragoza, 50009, Spain
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Chang-hua, Chang Hua, 50006, Taiwan
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Kaohsiung City, Sanmin, 80756, Taiwan
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Taipei, Special Municipality, 11217, Taiwan
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Taipei, Special Municipality, 11490, Taiwan
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Taipei, Taipei City, 100, Taiwan
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Taipei, Taipei City, 10449, Taiwan
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Bangkok, Bangkok, 10700, Thailand
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Dusit, Bangkok, 10300, Thailand
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Ban Phaeo, Changwat Samut Sakhon, 74120, Thailand
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Hat Yai, Changwat Songkhla, 90110, Thailand
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Chiang Mai, Chiang Mai, 50200, Thailand
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Brighton, England, BN2 5BE, United Kingdom
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London, England, WC1E 6AG, United Kingdom
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London, Greater London, EC1M 6BQ, United Kingdom
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Taunton, Somerset, TA1 5DA, United Kingdom
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Guildford, Surrey, GU2 7XX, United Kingdom
Clinical Trial Site 1
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Seoul, Seoul, 03080, South Korea
Clinical Trial Site 2
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Seoul, Seoul, 03080, South Korea

Conditions

Explore the condition pages connected to this study.

BREAST CANCER ER POSITIVE BREAST CANCER ER POSITIVE BREAST CANCER HER2-NEGATIVE BREAST CARCINOMA LOCALLY ADVANCED BREAST CANCER METASTATIC BREAST CANCER