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Neck manipulation may boost eye circulation, trial suggests

NCT ID NCT07688707

Symptom relief Sponsor: Yuzuncu Yil University Source: ClinicalTrials.gov ↗

What the study statuses mean

This study's is highlighted.

Recruitment status, easiest to join first

Recruiting now
This trial is taking on new participants right now.
Not yet recruiting
Registered, but not yet taking participants.
By invitation only
Not open to general applications. Only people the study team invites can take part.
Paused
Paused for now. It may or may not start again.
Ongoing
Running, but no longer taking on new participants.
Completed This study
The trial has finished. Results may not be published yet.
Stopped early
Stopped early, before it reached the end. That can be for many reasons, including safety.
Cancelled
Cancelled before anyone took part.

Expanded access (not trials)

Expanded access
Not a trial. This treatment can be requested outside a study, case by case, for people who qualify.
Expanded access (paused)
Not a trial. The treatment can normally be requested outside a study, but is unavailable right now.
Expanded access (ended)
Not a trial. The treatment could once be requested outside a study, but no longer can.
Approved
The treatment has been approved, so it is available normally rather than through this programme.

When the status isn't known

Details not published
The full record has not been published yet, so there is little to show here.
Status unknown
This status has not been confirmed recently, so it may be out of date.

First seen Jul 07, 2026 · Last updated Jul 08, 2026 · Updated 1 time

Summary

This study tests whether a single session of neck therapy (manipulation and mobilization) can increase blood flow to the retina and choroid in people with chronic neck pain. One hundred participants will receive either the therapy or a sham treatment, and their eye blood vessels will be measured using advanced imaging over two hours. The goal is to see if this type of therapy has immediate effects on eye circulation.

What this could mean

Our plain-language read of the trial. This is informational only, not medical advice or a prediction.

Active substance
Cervical manual therapy (manipulation and mobilization)
What this could lead to
If it works, this could show that neck therapy improves eye blood flow, potentially aiding conditions linked to poor eye circulation.
What could go wrong
This is a small, early-stage trial focused on short-term effects. Results may not apply to other groups or lead to lasting benefits.

This is an AI summary of the original study and may miss details. Read our disclaimer.

Study facts

What this study's own registry entry says, in plain language.

Phase

Not a phased trial

Phase numbers describe drug development. The registry uses this when they do not apply, as it does for trials of devices, procedures or behaviour changes, and for observational studies.

Participants

100 people

The number who actually took part.

Started

Feb 2026

Finished

May 2026

Lead sponsor

Other sponsor

The registry's catch-all category, for sponsors it does not file as a company, a government agency, or a research network.

Who can take part

This study's own entry requirements. Only the study team can say for certain whether you qualify.

Ages

18 to 70 years

Sex

Anyone

Healthy volunteers

Not accepted

This study is not open to healthy volunteers. The entry requirements below say who it is open to.

Show the full entry requirements

Copied word for word from the study's registry entry, so the wording is the study team's rather than ours.

Inclusion Criteria: * Age 18-70 years * Chronic mechanical neck pain lasting ≥3 months according to IASP criteria * Baseline VAS pain score ≥3 * Absence of cervical radiculopathy or myelopathy * Ability to provide informed consent and comply with study procedures * Adequate ocular image quality for OCTA assessment Exclusion Criteria: * Previous cervical spine surgery or major cervical trauma * Vertebrobasilar insufficiency or other contraindications to cervical manual therapy * Active inflammatory rheumatic disease or systemic connective tissue disorder * Known retinal or optic nerve disease that may affect OCTA measurements (glaucoma, diabetic retinopathy, age-related macular degeneration, optic neuritis, etc.) * Diabetes mellitus with end-organ complications or uncontrolled systemic hypertension (\>160/100 mmHg) * Refractive error \> ±6.0 D spherical equivalent or astigmatism \>3.0 D * Intraocular pressure \>21 mmHg * Previous ocular surgery, ocular trauma, or retinal laser treatment * Media opacity preventing adequate OCTA image acquisition * Pregnancy or lactation * Participation in another interventional clinical study within the previous 30 days

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As listed by the trial registrant

The condition terms exactly as the trial's registrant entered them.

Chronic mechanical neck pain

Contacts and locations

Locations

  • SBU Van Training and Research Hospital

    Van, 65000, Turkey (Türkiye)

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