Can a simple inhaled drug soothe Post-Surgery sore throats?
NCT ID NCT07746115
First seen Aug 04, 2026 · Last updated Aug 06, 2026 · Updated 2 times
Summary
This trial tests whether inhaling a low dose of ketamine before anesthesia can prevent the sore throat that often follows breathing tubes used during surgery. Adults aged 18-65 scheduled for elective surgery will receive either 25 mg, 50 mg, or a placebo mist before anesthesia. Researchers will track how many participants develop a sore throat and its severity over the first 24 hours after surgery, aiming to find the smallest effective dose with fewer side effects.
What this could mean
Our plain-language read of the trial. This is informational only — not medical advice or a prediction.
- Active substance
- Nebulized ketamine (25 mg or 50 mg) inhaled before anesthesia
- What this could lead to
- If effective, this could establish a low-dose, non-invasive way to prevent postoperative sore throat, improving patient comfort and satisfaction after surgery.
- What could go wrong
- The trial is relatively small and early, and the lower dose may not match the higher dose's effectiveness. Ketamine can cause side effects like nausea, dizziness, or hallucinations.
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As listed by the trial registrant
The condition terms exactly as the trial's registrant entered them.
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